U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC121627823 Sharpr-MPRA regulatory region 5399 [ Homo sapiens (human) ]

Gene ID: 121627823, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC121627823
Gene description
Sharpr-MPRA regulatory region 5399
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Activating DNase matched - State 10:DNaseD, primarily Duke DNase, candidate regulatory elements in more likely repressive locations). [provided by RefSeq, Jun 2021]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC121627823 in Genome Data Viewer
Location:
18p
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (13461610..13461904)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (13624489..13624783)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (13461609..13461903)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13116 Neighboring gene LDLRAD4 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13425961-13426523 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13446323-13447026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13447027-13447730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13454951-13455594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13455595-13456240 Neighboring gene uncharacterized LOC124904256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13474023-13474524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13474525-13475024 Neighboring gene microRNA 5190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13493407-13493936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13493937-13494464 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13500239-13500896 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13541887-13542410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13542411-13542932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13548044-13548993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13550257-13550758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13566667-13567294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13124 Neighboring gene microRNA 4526

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_075013.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    13461610..13461904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    13624489..13624783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases