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LOC121811726 Sharpr-MPRA regulatory region 1825 [ Homo sapiens (human) ]

Gene ID: 121811726, updated on 10-Oct-2023

Summary

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Gene symbol
LOC121811726
Gene description
Sharpr-MPRA regulatory region 1825
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in HepG2 liver carcinoma cells (group: HepG2 Activating non-DNase unmatched - State 22:ReprW, weaker Polycomb repression). [provided by RefSeq, Jul 2021]
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Genomic context

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Location:
10p
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (13400669..13400963)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (13413708..13414002)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (13442669..13442963)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RBIS pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:13371420-13371920 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:13371921-13372421 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:13376783-13377284 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:13377285-13377784 Neighboring gene selenophosphate synthetase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:13383617-13384469 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2154 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:13390478-13391268 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:13391269-13392060 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:13397412-13397565 Neighboring gene uncharacterized LOC105376419 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:13437106-13438069 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:13452136-13452642 Neighboring gene uncharacterized LOC105376420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3054 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:13481583-13482310 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2155 Neighboring gene BEN domain containing 7 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:13516079-13517278 Neighboring gene BEND7 divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_075828.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    13400669..13400963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    13413708..13414002
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases