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Bst1 bone marrow stromal cell antigen 1 [ Mus musculus (house mouse) ]

Gene ID: 12182, updated on 28-Oct-2024

Summary

Official Symbol
Bst1provided by MGI
Official Full Name
bone marrow stromal cell antigen 1provided by MGI
Primary source
MGI:MGI:105370
See related
Ensembl:ENSMUSG00000029082 AllianceGenome:MGI:105370
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bp3; BP-3; Ly65; Bsta1; CD157; 114/A10; A530073F09
Summary
Predicted to enable NAD+ nucleotidase, cyclic ADP-ribose generating and phosphorus-oxygen lyase activity. Predicted to be involved in several processes, including positive regulation of B cell proliferation; regulation of neutrophil chemotaxis; and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in uropod. Predicted to be active in plasma membrane. Is expressed in cerebellum; forebrain; and spleen white pulp. Orthologous to human BST1 (bone marrow stromal cell antigen 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in small intestine adult (RPKM 27.4), duodenum adult (RPKM 25.5) and 7 other tissues See more
Orthologs
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Genomic context

See Bst1 in Genome Data Viewer
Location:
5 B3; 5 23.84 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (43976235..44000810)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (43818880..43843468)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene predicted gene, 35762 Neighboring gene F-box and leucine-rich repeat protein 5 Neighboring gene STARR-seq mESC enhancer starr_12974 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:44215949-44216168 Neighboring gene STARR-positive B cell enhancer ABC_E8052 Neighboring gene STARR-seq mESC enhancer starr_12977 Neighboring gene STARR-seq mESC enhancer starr_12978 Neighboring gene STARR-seq mESC enhancer starr_12980 Neighboring gene predicted gene, 54296 Neighboring gene CD38 antigen Neighboring gene predicted gene 16015

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (1)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ nucleotidase, cyclic ADP-ribose generating ISO
Inferred from Sequence Orthology
more info
 
enables phosphorus-oxygen lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in uropod ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
Names
ADP-ribosyl cyclase 2
BP-3 alloantigen
BST-1
antigen BP3
bone marrow stromal antigen 1
cADPr hydrolase 2
cyclic ADP-ribose hydrolase 2
leukocyte antigen 65
ly-65
NP_033893.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009763.3NP_033893.2  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor

    See identical proteins and their annotated locations for NP_033893.2

    Status: VALIDATED

    Source sequence(s)
    AC140277
    Consensus CDS
    CCDS19264.1
    UniProtKB/Swiss-Prot
    Q64277, Q8BRY3
    UniProtKB/TrEMBL
    A0A0R4J190
    Related
    ENSMUSP00000098796.5, ENSMUST00000101237.8
    Conserved Domains (1) summary
    pfam02267
    Location:35261
    Rib_hydrolayse; ADP-ribosyl cyclase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    43976235..44000810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)