U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC122056877 Sharpr-MPRA regulatory region 13758 [ Homo sapiens (human) ]

Gene ID: 122056877, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC122056877
Gene description
Sharpr-MPRA regulatory region 13758
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional repressive element by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in both HepG2 liver carcinoma cells (group: HepG2 Repressive non-DNase unmatched - State 1:Tss, active promoter, TSS/CpG island region) and K562 erythroleukemia cells (group: K562 Repressive non-DNase unmatched - State 1:Tss). [provided by RefSeq, Jul 2021]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1p
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (53326757..53327051)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (53208967..53209261)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53792429..53792723)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378728 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:53719456-53719559 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:53719749-53719966 Neighboring gene LDL receptor related protein 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53736648-53737148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1044 Neighboring gene uncharacterized LOC105378726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53760223-53760764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53760765-53761305 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53773439-53774256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53774971-53775472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53775473-53775972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53777583-53778082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53784579-53785264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53785265-53785950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53790955-53791710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 905 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1045 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1046 Neighboring gene uncharacterized LOC105378731 Neighboring gene LRP8 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53805229-53805730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1047 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:53816803-53817658 Neighboring gene long intergenic non-protein coding RNA 2812

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_076333.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    53326757..53327051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    53208967..53209261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases