U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

C1qb complement component 1, q subcomponent, beta polypeptide [ Mus musculus (house mouse) ]

Gene ID: 12260, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
C1qbprovided by MGI
Official Full Name
complement component 1, q subcomponent, beta polypeptideprovided by MGI
Primary source
MGI:MGI:88224
See related
Ensembl:ENSMUSG00000036905 AllianceGenome:MGI:88224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adia
Summary
Enables identical protein binding activity. Involved in synapse pruning. Acts upstream of or within inner ear development. Located in postsynapse. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic membrane and extrinsic component of presynaptic membrane. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and integumental system. Orthologous to human C1QB (complement C1q B chain). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in mammary gland adult (RPKM 131.9), spleen adult (RPKM 123.8) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See C1qb in Genome Data Viewer
Location:
4 D3; 4 69.05 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136607437..136613511, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136880126..136886200, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Eph receptor B2 Neighboring gene predicted gene, 52708 Neighboring gene predicted gene, 31536 Neighboring gene complement component 1, q subcomponent, C chain Neighboring gene complement component 1, q subcomponent, alpha polypeptide

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2. Spielman L, et al. Acta Neuropathol, 2002 Feb. PMID 11810182
  2. Molecular cloning and characterization of the complementary DNA coding for the B-chain of murine Clq. Petry F, et al. FEBS Lett, 1989 Nov 20. PMID 2591537
  3. cDNA clones coding for the complete murine B chain of complement Clq: nucleotide and derived amino acid sequences. Wood L, et al. Immunol Lett, 1988 Jan. PMID 3258283
  4. cDNA clones coding for the complete murine B chain of complement C1q: nucleotide and derived amino acid sequences. Wood L, et al. Immunol Lett, 1988 Feb. PMID 3258843
  5. Gene expression of the A- and B-chain of mouse C1q in different tissues and the characterization of the recombinant A-chain. Petry F, et al. J Immunol, 1991 Dec 1. PMID 1940381

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in complement activation, classical pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in complement activation, classical pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inner ear development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synapse pruning IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
part_of complement component C1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of complement component C1 complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of complement component C1q complex ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular space HDA PubMed 
is_active_in extrinsic component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynapse IGI
Inferred from Genetic Interaction
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IGI
Inferred from Genetic Interaction
more info
 PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
complement C1q subcomponent subunit B
Names
adiponectin a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009777.3 → NP_033907.1  complement C1q subcomponent subunit B precursor

    See identical proteins and their annotated locations for NP_033907.1

    Status: VALIDATED

    Source sequence(s)
    AL627214
    Consensus CDS
    CCDS18810.1
    UniProtKB/Swiss-Prot
    P14106, Q3U793
    UniProtKB/TrEMBL
    Q3U6I5, Q3US82
    Related
    ENSMUSP00000040246.9, ENSMUST00000046384.9
    Conserved Domains (2) summary
    pfam01391
    Location:49 → 107
    Collagen; Collagen triple helix repeat (20 copies)
    cl23878
    Location:113 → 250
    C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    136607437..136613511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14106.2 GenPept UniProtKB/Swiss-Prot:P14106

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous