Cab39 calcium binding protein 39 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cab39provided by MGI
Official Full Name: calcium binding protein 39provided by MGI
Primary source: MGI:MGI:107438
See related: Ensembl:ENSMUSG00000036707 AllianceGenome:MGI:107438
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MO25; MO25alpha
Summary: Predicted to enable calcium ion binding activity; kinase binding activity; and protein serine/threonine kinase activator activity. Acts upstream of or within activation of protein kinase activity. Predicted to be located in Z disc. Predicted to be part of serine/threonine protein kinase complex. Is expressed in several structures, including clavicle; cranial ganglion; dorsal root ganglion; neural retina; and secondary oocyte. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CAB39 (calcium binding protein 39). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 37.9), colon adult (RPKM 29.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C5; 1 43.94 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (85707796..85779298)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (85793441..85851577)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calcium-binding protein 39 overexpression promotes macrophages from 'M1' into 'M2' phenotype and improves chondrocyte damage in osteoarthritis by activating the AMP-activated protein kinase/sirtuin 1 axis.
Title: Calcium-binding protein 39 overexpression promotes macrophages from 'M1' into 'M2' phenotype and improves chondrocyte damage in osteoarthritis by activating the AMP-activated protein kinase/sirtuin 1 axis.
miR-144/451 facilitates recovery from acute anemia by repressing Cab39/AMPK/mTOR
Title: miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia.
Cab39 differentially interacts with WNK4 and SPAK/OSR1 to switch the classic two kinase cascade into a signal kinase transduction
Title: A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.
Elevated miR-195 targets the LKB1/AMPK signaling axis in hypertrophic cardiomyopathy
Title: Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25.
Quantitative PCR revealed significantly reduced LKB1, MO25alpha, and STRADbeta mRNA in LKB1(-/-) muscle. These findings demonstrate that the LKB1-MO25-STRAD complex is the principal AMPKK in skeletal muscle.
Title: Characterization of the liver kinase B1-mouse protein-25 -Ste-20-related adaptor protein complex in adult mouse skeletal muscle.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125821 (e-PCR)
- UniSTS:162566

RH124770 (e-PCR)
- UniSTS:161592

RH136266 (e-PCR)
- UniSTS:210259

AA960512 (e-PCR)
- UniSTS:158821

RH128526 (e-PCR)
- UniSTS:211834

UniSTS:234167 (e-PCR)
- UniSTS:234167

C78372 (e-PCR)
- UniSTS:165085

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within activation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in response to thyroid hormone	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IC Inferred by Curator more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of serine/threonine protein kinase complex	IEA Inferred from Electronic Annotation more info
part_of serine/threonine protein kinase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcium-binding protein 39

Names: calcium binding protein, 39 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355046.2 → NP_001341975.1 calcium-binding protein 39 isoform 1

Status: VALIDATED

Source sequence(s)

AC107707, AC161342

Consensus CDS

CCDS15112.1

UniProtKB/Swiss-Prot

Q06138, Q8VDZ8

Conserved Domains (1) summary

pfam08569
Location:5 → 334

Mo25; Mo25-like
NM_001355047.2 → NP_001341976.1 calcium-binding protein 39 isoform 1

Status: VALIDATED

Source sequence(s)

AC107707, AC161342

Consensus CDS

CCDS15112.1

UniProtKB/Swiss-Prot

Q06138, Q8VDZ8

Conserved Domains (1) summary

pfam08569
Location:5 → 334

Mo25; Mo25-like
NM_001420006.1 → NP_001406935.1 calcium-binding protein 39 isoform 1

Status: VALIDATED

Source sequence(s)

AC107707, AC161342

UniProtKB/Swiss-Prot

Q06138, Q8VDZ8

Related

ENSMUSP00000095270.3, ENSMUST00000097666.4
NM_001420007.1 → NP_001406936.1 calcium-binding protein 39 isoform 1

Status: VALIDATED

Source sequence(s)

AC107707, AC161342

UniProtKB/Swiss-Prot

Q06138, Q8VDZ8
NM_001420009.1 → NP_001406938.1 calcium-binding protein 39 isoform 1

Status: VALIDATED

Source sequence(s)

AC107707, AC161342

UniProtKB/Swiss-Prot

Q06138, Q8VDZ8
NM_001420010.1 → NP_001406939.1 calcium-binding protein 39 isoform 1

Status: VALIDATED

Source sequence(s)

AC107707, AC161342

UniProtKB/Swiss-Prot

Q06138, Q8VDZ8
NM_001420011.1 → NP_001406940.1 calcium-binding protein 39 isoform 1

Status: VALIDATED

Source sequence(s)

AC107707, AC161342

UniProtKB/Swiss-Prot

Q06138, Q8VDZ8
NM_001420012.1 → NP_001406941.1 calcium-binding protein 39 isoform 1

Status: VALIDATED

Source sequence(s)

AC107707, AC161342

UniProtKB/Swiss-Prot

Q06138, Q8VDZ8
NM_001420013.1 → NP_001406942.1 calcium-binding protein 39 isoform 1

Status: VALIDATED

Source sequence(s)

AC107707, AC161342

UniProtKB/Swiss-Prot

Q06138, Q8VDZ8
NM_001420014.1 → NP_001406943.1 calcium-binding protein 39 isoform 1

Status: VALIDATED

Source sequence(s)

AC107707, AC161342

UniProtKB/Swiss-Prot

Q06138, Q8VDZ8
NM_001420015.1 → NP_001406944.1 calcium-binding protein 39 isoform 1

Status: VALIDATED

Source sequence(s)

AC107707, AC161342

UniProtKB/Swiss-Prot

Q06138, Q8VDZ8
NM_001420016.1 → NP_001406945.1 calcium-binding protein 39 isoform 2

Status: VALIDATED

Source sequence(s)

AC107707, AC161342
NM_001420017.1 → NP_001406946.1 calcium-binding protein 39 isoform 3

Status: VALIDATED

Source sequence(s)

AC107707, AC161342
NM_001420018.1 → NP_001406947.1 calcium-binding protein 39 isoform 3

Status: VALIDATED

Source sequence(s)

AC107707, AC161342
NM_001420019.1 → NP_001406948.1 calcium-binding protein 39 isoform 3

Status: VALIDATED

Source sequence(s)

AC107707, AC161342
NM_001420020.1 → NP_001406949.1 calcium-binding protein 39 isoform 4

Status: VALIDATED

Source sequence(s)

AC107707, AC161342
NM_001420021.1 → NP_001406950.1 calcium-binding protein 39 isoform 5

Status: VALIDATED

Source sequence(s)

AC107707, AC161342
NM_001420022.1 → NP_001406951.1 calcium-binding protein 39 isoform 5

Status: VALIDATED

Source sequence(s)

AC107707, AC161342
NM_133781.6 → NP_598542.3 calcium-binding protein 39 isoform 1

See identical proteins and their annotated locations for NP_598542.3

Status: VALIDATED

Source sequence(s)

AC107707, AC161342

Consensus CDS

CCDS15112.1

UniProtKB/Swiss-Prot

Q06138, Q8VDZ8

Related

ENSMUSP00000108987.2, ENSMUST00000113360.8

Conserved Domains (1) summary

pfam08569
Location:5 → 334

Mo25; Mo25-like