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LOC122889033 Sharpr-MPRA regulatory region 1670 [ Homo sapiens (human) ]

Gene ID: 122889033, updated on 10-Oct-2023

Summary

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Gene symbol
LOC122889033
Gene description
Sharpr-MPRA regulatory region 1670
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional repressive element by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Repressive non-DNase unmatched - State 13:Ctcf, distal CTCF/candidate insulator without open chromatin). [provided by RefSeq, Oct 2021]
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Genomic context

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Location:
3p
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (11045603..11045897)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (11040064..11040358)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (11087289..11087583)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 11 Neighboring gene uncharacterized LOC105376950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:10976470-10977424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:10977664-10978170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:10978171-10978676 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:11009752-11010252 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:11010253-11010753 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:11024802-11025580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:11034754-11035278 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_64297 Neighboring gene SLC6A1 antisense RNA 1 Neighboring gene solute carrier family 6 member 1 Neighboring gene uncharacterized LOC101927467 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:11178289-11179488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19426 Neighboring gene uncharacterized LOC105376951 Neighboring gene histamine receptor H1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_077165.1 

    Range
    101..395
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    11045603..11045897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    11040064..11040358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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