Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cacna1eprovided by MGI
Official Full Name: calcium channel, voltage-dependent, R type, alpha 1E subunitprovided by MGI
Primary source: MGI:MGI:106217
See related: Ensembl:ENSMUSG00000004110 AllianceGenome:MGI:106217
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BII; Cach6; Cav2.3; Cchra1; alpha1E; Cacnl1a6; A430040I15
Summary: This gene encodes an integral membrane protein that belongs to the calcium channel alpha-1 subunits family. Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes. Voltage-dependent calcium channels are multi-subunit complexes, comprised of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The isoform alpha-1E gives rise to R-type calcium currents and belongs to the high-voltage activated group. Calcium channels containing the alpha-1E subunit may be involved in the modulation of neuronal firing patterns, an important component of information processing. [provided by RefSeq, Jul 2008]
Expression: Biased expression in frontal lobe adult (RPKM 6.4), cortex adult (RPKM 6.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G3; 1 66.14 cM

Exon count:: 56

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (154266552..154760374, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (154390806..154884785, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability.
Title: Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability.
L-cysteine modulates visceral nociception mediated by the CaV2.3 R-type calcium channels.
Title: L-cysteine modulates visceral nociception mediated by the Ca(V)2.3 R-type calcium channels.
GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals.
Title: GABA(B) receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals.
Proteomic analysis of olfactory bulb suggests CACNA1E as a promoter of CREB signaling in microbiota-induced depression.
Title: Proteomic analysis of olfactory bulb suggests CACNA1E as a promoter of CREB signaling in microbiota-induced depression.
Cav2.3 channels are regulators of nigral neuronal viability. Cav2.3 knockout reduced activity-associated nigral somatic Ca2+ signals and Ca2+-dependent after-hyperpolarizations, and afforded full protection from degeneration in vivo in a neurotoxin Parkinson's mouse model. Cav2.3 deficiency upregulated transcripts for NCS-1. Conversely, NCS-1 knockout exacerbated nigral neurodegeneration and downregulated Cav2.3.
Title: Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease.
The ex vivo neuronal setup of the isolated and superfused murine retina demonstrates a transient effect of bilirubin on neuronal signaling only when Cav2.3/R-type channels are present. Modulation of Cav2.3/R-type Ca2+ channels may contribute to the pathophysiological cascades of vasospasm or delayed cerebral ischemia.
Title: Unconjugated bilirubin modulates neuronal signaling only in wild-type mice, but not after ablation of the R-type/Ca(v) 2.3 voltage-gated calcium channel.
The results of this study showed that Cav2.3 is a novel mechanistic target for a key pronociceptive miRNA, miR-34c-5p.
Title: miR-34c-5p functions as pronociceptive microRNA in cancer pain by targeting Cav2.3 containing calcium channels.
Data show that apamin boosts evoked excitatory postsynaptic potentials (EPSPs) in CaV2.3 R-Type Ca2+ Channel knockout (CaV2.3-/-) mice.
Title: Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice.
under conditions of Zn2+ deficiency, ablation or dysfunction of Cav2.3 channels may lead to severe disturbances in glucose homeostasis.
Title: Diethyldithiocarbamate-mediated zinc ion chelation reveals role of Cav2.3 channels in glucagon secretion.
Cav2.1-2.3 have unique contributions to the dynamics at the Schaffer collateral synapse that are engaged by the complex patterns of afferent activity seen in vivo
Title: Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

Cacna1e (e-PCR), detects polymorphism
- UniSTS:141211

D1Mit142 (e-PCR), detects polymorphism
- UniSTS:128479

NoName (e-PCR)
- UniSTS:234235

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fear response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of somatostatin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: voltage-dependent R-type calcium channel subunit alpha-1E

Names: brain calcium channel II; calcium channel, L type, alpha-1 polypeptide; calcium channel, voltage-dependent, L type, alpha 1E subunit; voltage-gated calcium channel subunit alpha Cav2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009782.3 → NP_033912.2 voltage-dependent R-type calcium channel subunit alpha-1E

Status: REVIEWED

Source sequence(s)

AC099707, AC101727, AC122040

Consensus CDS

CCDS78710.1

UniProtKB/TrEMBL

A0A087WS83, B2RWX7

Related

ENSMUSP00000140937.2, ENSMUST00000187541.7

Conserved Domains (5) summary

pfam00520
Location:1498 → 1737

Ion_trans; Ion transport protein

pfam05439
Location:341 → 374

JTB; Jumping translocation breakpoint protein (JTB)

pfam07816
Location:2013 → 2117

DUF1645; Protein of unknown function (DUF1645)

pfam08763
Location:1810 → 1884

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1745 → 1808

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

154266552..154760374 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243929.1 → XP_030099789.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1626 → 1883

Ion_trans; Ion transport protein

pfam08763
Location:1956 → 2029

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2168 → 2243

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1892 → 1945

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017312578.3 → XP_017168067.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1626 → 1883

Ion_trans; Ion transport protein

pfam08763
Location:1956 → 2029

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2168 → 2243

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1892 → 1945

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017312848.1 → XP_017168337.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X14

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1480 → 1737

Ion_trans; Ion transport protein

pfam08763
Location:1810 → 1883

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2022 → 2097

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1746 → 1799

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017312712.1 → XP_017168201.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X8

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1596 → 1853

Ion_trans; Ion transport protein

pfam08763
Location:1926 → 1999

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2138 → 2213

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1862 → 1915

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017312660.1 → XP_017168149.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X6

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1607 → 1864

Ion_trans; Ion transport protein

pfam08763
Location:1937 → 2010

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2149 → 2224

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1873 → 1926

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017312628.1 → XP_017168117.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X4

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1622 → 1879

Ion_trans; Ion transport protein

pfam08763
Location:1952 → 2025

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2164 → 2239

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1888 → 1941

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017312642.1 → XP_017168131.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X5

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1622 → 1879

Ion_trans; Ion transport protein

pfam08763
Location:1952 → 2025

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2164 → 2239

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1888 → 1941

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017312619.1 → XP_017168108.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X3

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1626 → 1883

Ion_trans; Ion transport protein

pfam08763
Location:1956 → 2029

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2164 → 2239

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1892 → 1945

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017312730.1 → XP_017168219.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X9

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1626 → 1883

Ion_trans; Ion transport protein

pfam08763
Location:1956 → 2029

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2125 → 2200

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1892 → 1945

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017312613.1 → XP_017168102.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X2

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1626 → 1883

Ion_trans; Ion transport protein

pfam08763
Location:1956 → 2029

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2168 → 2243

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1892 → 1945

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_030243926.1 → XP_030099786.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1626 → 1883

Ion_trans; Ion transport protein

pfam08763
Location:1956 → 2029

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2168 → 2243

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1892 → 1945

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_011247909.4 → XP_011246211.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

See identical proteins and their annotated locations for XP_011246211.1

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1626 → 1883

Ion_trans; Ion transport protein

pfam08763
Location:1956 → 2029

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2168 → 2243

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1892 → 1945

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_011247916.4 → XP_011246218.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X14

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1480 → 1737

Ion_trans; Ion transport protein

pfam08763
Location:1810 → 1883

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2022 → 2097

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1746 → 1799

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_030244154.2 → XP_030100014.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X15

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam17069
Location:1966 → 2090

RSRP; Arginine/Serine-Rich protein 1

pfam00520
Location:1431 → 1688

Ion_trans; Ion transport protein

pfam08763
Location:1761 → 1834

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1697 → 1750

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017312745.2 → XP_017168234.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X10

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1626 → 1883

Ion_trans; Ion transport protein

pfam08763
Location:1956 → 2029

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2121 → 2196

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1892 → 1945

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017312824.2 → XP_017168313.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X13

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1607 → 1864

Ion_trans; Ion transport protein

pfam08763
Location:1937 → 2010

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2102 → 2177

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1873 → 1926

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017312766.2 → XP_017168255.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X11

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1626 → 1883

Ion_trans; Ion transport protein

pfam08763
Location:1956 → 2029

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2121 → 2196

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1892 → 1945

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017312795.2 → XP_017168284.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X12

UniProtKB/TrEMBL

B2RWX7

Conserved Domains (4) summary

pfam00520
Location:1607 → 1864

Ion_trans; Ion transport protein

pfam08763
Location:1937 → 2010

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2102 → 2177

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1873 → 1926

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017312682.2 → XP_017168171.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X7

UniProtKB/TrEMBL

B2RWX7

Related

ENSMUSP00000148507.2, ENSMUST00000211821.2

Conserved Domains (4) summary

pfam00520
Location:1607 → 1864

Ion_trans; Ion transport protein

pfam08763
Location:1937 → 2010

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10500
Location:2145 → 2220

SR-25; Nuclear RNA-splicing-associated protein

pfam16905
Location:1873 → 1926

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036155941.1 → XP_036011834.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X16

UniProtKB/Swiss-Prot

Q61290

Conserved Domains (3) summary

pfam00520
Location:1626 → 1883

Ion_trans; Ion transport protein

pfam08763
Location:1956 → 2029

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1892 → 1945

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006529105.5 → XP_006529168.1 voltage-dependent R-type calcium channel subunit alpha-1E isoform X17

Conserved Domains (1) summary

pfam00520
Location:1626 → 1883

Ion_trans; Ion transport protein