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TC2N tandem C2 domains, nuclear [ Homo sapiens (human) ]

Gene ID: 123036, updated on 5-Mar-2024

Summary

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Official Symbol
TC2Nprovided by HGNC
Official Full Name
tandem C2 domains, nuclearprovided by HGNC
Primary source
HGNC:HGNC:19859
See related
Ensembl:ENSG00000165929 MIM:619305; AllianceGenome:HGNC:19859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C2CD1; TAC2N; Tac2-N; MTAC2D1; C14orf47
Summary
Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in gall bladder (RPKM 19.6), stomach (RPKM 15.2) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
14q32.12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (91779746..91867536, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (86009200..86097026, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (92246090..92333880, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated auxiliary subunit beta Neighboring gene pyruvate dehydrogenase kinase 3 pseudogene Neighboring gene small nucleolar RNA U3 Neighboring gene MPRA-validated peak2233 silencer Neighboring gene uncharacterized LOC124903362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8925 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:92363455-92363968 Neighboring gene fibulin 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:92392675-92393174 Neighboring gene thyroid hormone receptor interactor 11 Neighboring gene prothymosin alpha pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers. Li H, et al. Front Immunol, 2021. PMID 34925334, Free PMC Article
  2. Tac2-N acts as a novel oncogene and promotes tumor metastasis via activation of NF-κB signaling in lung cancer. Hao X, et al. J Exp Clin Cancer Res, 2019 Aug 30. PMID 31466523, Free PMC Article
  3. TC2N, a novel oncogene, accelerates tumor progression by suppressing p53 signaling pathway in lung cancer. Hao XL, et al. Cell Death Differ, 2019 Jul. PMID 30254375, Free PMC Article
  4. Tac2-N, an atypical C-type tandem C2 protein localized in the nucleus. Fukuda M, et al. FEBS Lett, 2001 Aug 17. PMID 11526914
  5. Impact on venous thrombosis risk of newly discovered gene variants associated with FVIII and VWF plasma levels. Morange PE, et al. J Thromb Haemost, 2011 Jan. PMID 21029358

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
    Title: TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
  2. TC2N Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Targeting the Wnt/beta-Catenin Signaling Pathway.
    Title: TC2N Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Targeting the Wnt/β-Catenin Signaling Pathway.
  3. TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers.
    Title: TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers.
  4. The TC2N attenuates p53 signaling pathway through inhibiting Cdk5-induced phosphorylation of p53 via inducing Cdk5 degradation or disrupting the interaction between Cdk5 and p53.
    Title: TC2N, a novel oncogene, accelerates tumor progression by suppressing p53 signaling pathway in lung cancer.
  5. Study provided proof of principle to show that Tac2-N serves as a novel oncogene gene and plays an important role in the progression and metastasis of lung cancer.
    Title: Tac2-N acts as a novel oncogene and promotes tumor metastasis via activation of NF-κB signaling in lung cancer.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Impact on venous thrombosis risk of newly discovered gene variants associated with FVIII and VWF plasma levels.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of tandem C2 domains, nuclear (TC2N) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36557, DKFZp779J0742

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tandem C2 domains nuclear protein
Names
C2 calcium-dependent domain containing 1
membrane targeting (tandem) C2 domain containing 1
tandem C2 protein in nucleus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128595.3 → NP_001122067.2  tandem C2 domains nuclear protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AL121839
    Consensus CDS
    CCDS9897.1
    UniProtKB/Swiss-Prot
    Q8N9U0
    Related
    ENSP00000353802.5, ENST00000360594.9
    Conserved Domains (2) summary
    cd08684
    Location:240 → 342
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:353 → 487
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

  2. NM_001128596.3 → NP_001122068.2  tandem C2 domains nuclear protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AL121839, AL590328
    Consensus CDS
    CCDS9897.1
    UniProtKB/Swiss-Prot
    Q8N9U0
    Related
    ENSP00000387882.2, ENST00000435962.7
    Conserved Domains (2) summary
    cd08684
    Location:240 → 342
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:353 → 487
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

  3. NM_001289134.2 → NP_001276063.2  tandem C2 domains nuclear protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL121839
    Consensus CDS
    CCDS73679.1
    Related
    ENSP00000451317.1, ENST00000556018.5
    Conserved Domains (2) summary
    cd08692
    Location:289 → 423
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cl14603
    Location:240 → 285
    C2; C2 domain

  4. NM_152332.6 → NP_689545.2  tandem C2 domains nuclear protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AL121839
    Consensus CDS
    CCDS9897.1
    UniProtKB/Swiss-Prot
    Q8N9U0
    Related
    ENSP00000343199.5, ENST00000340892.9
    Conserved Domains (2) summary
    cd08684
    Location:240 → 342
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:353 → 487
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    91779746..91867536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187598.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    247541..304250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    86009200..86097026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N9U0.2 GenPept UniProtKB/Swiss-Prot:Q8N9U0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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