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Calca calcitonin/calcitonin-related polypeptide, alpha [ Mus musculus (house mouse) ]

Gene ID: 12310, updated on 5-Nov-2024

Summary

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Official Symbol
Calcaprovided by MGI
Official Full Name
calcitonin/calcitonin-related polypeptide, alphaprovided by MGI
Primary source
MGI:MGI:2151253
See related
Ensembl:ENSMUSG00000030669 AllianceGenome:MGI:2151253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CA; Ct; Ctn; Calc; Cgrp; CGRP1; Calc1; CGRP-1
Summary
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide (CGRP) and katacalcin. Alternative splicing of the mRNA results in multiple variants that encode either calcitonin or CGRP preproproteins. Post-translational processing of the calcitonin and CGRP propeptides results in either calcitonin and katacalcin, or CGRP, respectively. Calcitonin and katacalcin modulate calcium levels in the blood stream. CGRP can function as a vasodilator and play a role in the transmission of pain. The human homolog of CGRP was found to have antimicrobial activity. [provided by RefSeq, Mar 2015]
Expression
Biased expression in CNS E11.5 (RPKM 1.9), cerebellum adult (RPKM 1.7) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Calca in Genome Data Viewer
Location:
7 F1; 7 59.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (114225223..114236145, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (114625981..114636910, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933406I18 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:121575722-121576022 Neighboring gene STARR-positive B cell enhancer ABC_E8203 Neighboring gene phosphodiesterase 3B, cGMP-inhibited Neighboring gene STARR-positive B cell enhancer mm9_chr7:121623448-121623749 Neighboring gene STARR-positive B cell enhancer ABC_E9702 Neighboring gene STARR-seq mESC enhancer starr_19929 Neighboring gene STARR-seq mESC enhancer starr_19930 Neighboring gene cytochrome P450, family 2, subfamily r, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_19932 Neighboring gene STARR-seq mESC enhancer starr_19933 Neighboring gene Rho GTPase activating protein 21 pseudogene Neighboring gene ribosomal protein L5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Calcitonin gene-related peptide is involved in inflammatory pain but not in postoperative pain. Ishida K, et al. Anesthesiology, 2014 Nov. PMID 24992521
  2. Low-intensity pulsed ultrasound improves osseointegration of dental implant in mice by inducing local neuronal production of αCGRP. Jiang Y, et al. Arch Oral Biol, 2020 Jul. PMID 32371135
  3. Deficiency of alpha-calcitonin gene-related peptide induces inflammatory responses and lethality in sepsis. Lee JK, et al. Cytokine, 2013 Nov. PMID 24021706
  4. Targeted overexpression of calcitonin in gonadotrophs of transgenic mice leads to chronic hypoprolactinemia. Yuan R, et al. Mol Cell Endocrinol, 2005 Jan 14. PMID 15607543
  5. An ongoing role of α-calcitonin gene-related peptide as part of a protective network against hypertension, vascular hypertrophy, and oxidative stress. Smillie SJ, et al. Hypertension, 2014 May. PMID 24516108

See all (563) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lack of alpha CGRP exacerbates the development of atherosclerosis in ApoE-knockout mice.
    Title: Lack of alpha CGRP exacerbates the development of atherosclerosis in ApoE-knockout mice.
  2. A Vestibular Challenge Combined with Calcitonin Gene-Related Peptide (CGRP) Promotes Anxiety-Like Behaviors.
    Title: A Vestibular Challenge Combined with Calcitonin Gene-Related Peptide (CGRP) Promotes Anxiety-Like Behaviors.
  3. Activation of CGRP receptor-mediated signaling promotes tendon-bone healing.
    Title: Activation of CGRP receptor-mediated signaling promotes tendon-bone healing.
  4. Loss of calcitonin gene-related peptide (alphaCGRP) and use of a vestibular challenge highlight balance deficiencies in aging mice.
    Title: Loss of calcitonin gene-related peptide (αCGRP) and use of a vestibular challenge highlight balance deficiencies in aging mice.
  5. Transcript-dependent effects of the CALCA gene on the progression of post-traumatic osteoarthritis in mice.
    Title: Transcript-dependent effects of the CALCA gene on the progression of post-traumatic osteoarthritis in mice.
  6. Sensory nerves, but not sympathetic nerves, promote reparative dentine formation after dentine injury via CGRP-mediated angiogenesis: An in vivo study.
    Title: Sensory nerves, but not sympathetic nerves, promote reparative dentine formation after dentine injury via CGRP-mediated angiogenesis: An in vivo study.
  7. Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation.
    Title: Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation.
  8. Elucidating the Ability of CGRP to Modulate Microvascular Events in Mouse Skin.
    Title: Elucidating the Ability of CGRP to Modulate Microvascular Events in Mouse Skin.
  9. Calcitonin gene-related peptide: An intra-articular therapeutic target for TMJ disorders.
    Title: Calcitonin gene-related peptide: An intra-articular therapeutic target for TMJ disorders.
  10. [Calcitonin gene-related peptides protect against oxidative stress-induced lung injury via increasing autophagy in neonatal rats].
    Title: [Calcitonin gene-related peptides protect against oxidative stress-induced lung injury via increasing autophagy in neonatal rats].
Submit: New GeneRIF Correction See all GeneRIFs (168)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (8) 
  • Targeted (11)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcitonin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcitonin receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcitonin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within activation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within activation of adenylate cyclase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of cell adhesion IDA
Inferred from Direct Assay
more info
  
acts_upstream_of_or_within cellular response to nerve growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within feeding behavior IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of blood pressure ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of smooth muscle contraction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nervous system process involved in regulation of systemic arterial blood pressure ISA
Inferred from Sequence Alignment
more info
 PubMed 
acts_upstream_of_or_within neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell adhesion IDA
Inferred from Direct Assay
more info
  
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of smooth muscle contraction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sperm capacitation ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calcitonin gene-related peptide 1
Names
alpha-type CGRP
calcitonin gene-related peptide I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033954.3 → NP_001029126.1  calcitonin gene-related peptide 1 isoform Cgrp preproprotein

    See identical proteins and their annotated locations for NP_001029126.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks the 3' terminal exon and has two alternate 3' exons, compared to variant 1. The resulting isoform (Cgrp) is shorter and has a distinct C-terminus, compared to isoform Calca. Both variants 2 and 3 encode the same isoform Cgrp.
    Source sequence(s)
    BB749493, BC028771, BU842988, CJ060164
    Consensus CDS
    CCDS21762.1
    UniProtKB/Swiss-Prot
    Q99JA0
    Related
    ENSMUSP00000032906.5, ENSMUST00000032906.11
    Conserved Domains (1) summary
    pfam00214
    Location:1 → 124
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

  2. NM_001289444.1 → NP_001276373.1  calcitonin gene-related peptide 1 isoform Cgrp preproprotein

    See identical proteins and their annotated locations for NP_001276373.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an altenate splice site in the 5' UTR, lacks the 3' terminal exon and has two alternate 3' exons, compared to variant 1. The resulting isoform (Cgrp) is shorter and has a distinct C-terminus, compared to isoform Calca. Both variants 2 and 3 encode the same isoform Cgrp.
    Source sequence(s)
    AF330212, BB749493, BC028771, BU842988, CJ057527, CJ060164
    Consensus CDS
    CCDS21762.1
    UniProtKB/Swiss-Prot
    Q99JA0
    Conserved Domains (1) summary
    pfam00214
    Location:1 → 124
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

  3. NM_001305616.1 → NP_001292545.1  calcitonin gene-related peptide 1 isoform Calca preproprotein

    See identical proteins and their annotated locations for NP_001292545.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Both variants 1 and 4 encode the same isoform Calca.
    Source sequence(s)
    AC156617, AK132582, BC030071, CJ060164
    Consensus CDS
    CCDS21763.1
    UniProtKB/Swiss-Prot
    P70160, Q8K1K5
    UniProtKB/TrEMBL
    Q3V1A7
    Related
    ENSMUSP00000146328.2, ENSMUST00000206853.2
    Conserved Domains (1) summary
    pfam00214
    Location:1 → 121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

  4. NM_007587.2 → NP_031613.2  calcitonin gene-related peptide 1 isoform Calca preproprotein

    See identical proteins and their annotated locations for NP_031613.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (Calca). Both variants 1 and 4 encode the same protein.
    Source sequence(s)
    BC030071, CJ060164, X97991
    Consensus CDS
    CCDS21763.1
    UniProtKB/Swiss-Prot
    P70160, Q8K1K5
    UniProtKB/TrEMBL
    Q3V1A7
    Related
    ENSMUSP00000032907.8, ENSMUST00000032907.9
    Conserved Domains (1) summary
    pfam00214
    Location:1 → 121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    114225223..114236145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241660.4 → XP_011239962.1  calcitonin gene-related peptide 1 isoform X2

    See identical proteins and their annotated locations for XP_011239962.1

    UniProtKB/Swiss-Prot
    Q99JA0
    Conserved Domains (1) summary
    pfam00214
    Location:1 → 124
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

  2. XM_030242032.1 → XP_030097892.1  calcitonin gene-related peptide 1 isoform X2

    UniProtKB/Swiss-Prot
    Q99JA0
    Conserved Domains (1) summary
    pfam00214
    Location:1 → 124
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

  3. XM_030242031.1 → XP_030097891.1  calcitonin gene-related peptide 1 isoform X1

    UniProtKB/Swiss-Prot
    P70160, Q8K1K5
    UniProtKB/TrEMBL
    Q3V1A7
    Conserved Domains (1) summary
    pfam00214
    Location:1 → 121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70160.1 GenPept UniProtKB/Swiss-Prot:P70160
Q99JA0.1 GenPept UniProtKB/Swiss-Prot:Q99JA0

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