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Nr1i3 nuclear receptor subfamily 1, group I, member 3 [ Mus musculus (house mouse) ]

Gene ID: 12355, updated on 2-Nov-2024

Summary

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Official Symbol
Nr1i3provided by MGI
Official Full Name
nuclear receptor subfamily 1, group I, member 3provided by MGI
Primary source
MGI:MGI:1346307
See related
Ensembl:ENSMUSG00000005677 AllianceGenome:MGI:1346307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAR; MB67; Care2; ESTM32; CAR-beta
Summary
Enables DNA binding activity. Acts upstream of or within negative regulation of DNA-templated transcription. Located in cytosol and nucleus. Is expressed in several structures, including genitourinary system; gut; heart; liver; and thymus. Orthologous to human NR1I3 (nuclear receptor subfamily 1 group I member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 52.5), duodenum adult (RPKM 13.0) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Nr1i3 in Genome Data Viewer
Location:
1 H3; 1 79.21 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171041503..171046414)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171213934..171218845)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2018 Neighboring gene myelin protein zero Neighboring gene Purkinje cell protein 4-like 1 Neighboring gene translocase of outer mitochondrial membrane 40-like Neighboring gene STARR-positive B cell enhancer ABC_E1573 Neighboring gene apolipoprotein A-II Neighboring gene Fc receptor, IgE, high affinity I, gamma polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development. Kuwata K, et al. Toxicol Sci, 2016 Jun. PMID 26928356
  2. Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites. Stoner MA, et al. Nucleic Acids Res, 2007. PMID 17355985, Free PMC Article
  3. Effects of TK promotor and hepatocyte nuclear factor-4 in CAR-mediated transcriptional activity of phenobarbital responsive unit of CYP2B gene in monkey kidney epithelial-derived cell line COS-7. Min G. Ann N Y Acad Sci, 2006 Dec. PMID 17341620
  4. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Yueh MF, et al. Proc Natl Acad Sci U S A, 2014 Dec 2. PMID 25404284, Free PMC Article
  5. The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of non-alcoholic steatohepatitis. Yamazaki Y, et al. Gut, 2007 Apr. PMID 16950832, Free PMC Article

See all (211) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation.
    Title: Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation.
  2. CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders.
    Title: CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders.
  3. Impact of Neonatal Activation of Nuclear Receptor CAR (Nr1i3) on Cyp2 Gene Expression in Adult Mouse Liver.
    Title: Impact of Neonatal Activation of Nuclear Receptor CAR (Nr1i3) on Cyp2 Gene Expression in Adult Mouse Liver.
  4. Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR).
    Title: Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR).
  5. CAR directs T cell adaptation to bile acids in the small intestine.
    Title: CAR directs T cell adaptation to bile acids in the small intestine.
  6. Activation of the Akt pathway by a constitutive androstane receptor agonist results in beta-catenin activation.
    Title: Activation of the Akt pathway by a constitutive androstane receptor agonist results in β-catenin activation.
  7. Nuclear receptor CAR-ERalpha signaling regulates the estrogen sulfotransferase gene in the liver.
    Title: Nuclear receptor CAR-ERα signaling regulates the estrogen sulfotransferase gene in the liver.
  8. CAR contributes an expansive role regulating energy metabolism, significantly impacting glucose and monocarboxylic acid utilization, fatty acid metabolism and lipid homeostasis, through receptor-mediated regulation of several genes in multiple associated pathways.
    Title: Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism.
  9. RNA-Seq performed from livers of adult male C57BL/6 mice treated with PXR or CAR agonists identified differentially expressed lncRNAs-protein-coding genes (PCGs) pairs that displayed a high coregulatory pattern by PXR and CAR activation. Study was among the first to demonstrate that lncRNAs are regulated by PXR and CAR activation and that they may be important regulators of PCGs involved in xenobiotic metabolism.
    Title: Regulation of Hepatic Long Noncoding RNAs by Pregnane X Receptor and Constitutive Androstane Receptor Agonists in Mouse Liver.
  10. new findings in this report link an important role in CAR activation that is dependent upon oxidative stress.
    Title: Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress.
Submit: New GeneRIF Correction See all GeneRIFs (111)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (7)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107281

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nuclear receptor subfamily 1 group I member 3
Names
constitutive androstane receptor
constitutively transactivates RAREs
orphan nuclear receptor MB67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243062.1 → NP_001229991.1  nuclear receptor subfamily 1 group I member 3 isoform 2

    See identical proteins and their annotated locations for NP_001229991.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region which results in a frameshift, compared to variant 1. This results in a shorter and distinct C-terminus in isoform 2, compared to isoform 1.
    Source sequence(s)
    AI132241, AK133515
    Consensus CDS
    CCDS56654.1
    UniProtKB/Swiss-Prot
    O35627
    Related
    ENSMUSP00000074915.6, ENSMUST00000075469.12
    Conserved Domains (2) summary
    cd07156
    Location:21 → 92
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
    cl11397
    Location:116 → 281
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  2. NM_001243063.1 → NP_001229992.1  nuclear receptor subfamily 1 group I member 3 isoform 3

    See identical proteins and their annotated locations for NP_001229992.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an in-frame alternate splice site in the 3' coding, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AI132241, AK133515, BC089541
    Consensus CDS
    CCDS56655.1
    UniProtKB/TrEMBL
    Q5FW96
    Related
    ENSMUSP00000106960.2, ENSMUST00000111328.8
    Conserved Domains (2) summary
    cd07156
    Location:21 → 92
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
    cl11397
    Location:116 → 355
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  3. NM_009803.5 → NP_033933.2  nuclear receptor subfamily 1 group I member 3 isoform 1

    See identical proteins and their annotated locations for NP_033933.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC163497, AI132241, AK133515
    Consensus CDS
    CCDS15480.1
    UniProtKB/Swiss-Prot
    O35627, O35628, Q3V008
    Related
    ENSMUSP00000005820.5, ENSMUST00000005820.11
    Conserved Domains (2) summary
    cd07156
    Location:21 → 92
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
    cl11397
    Location:116 → 356
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171041503..171046414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496628.2 → XP_006496691.1  nuclear receptor subfamily 1 group I member 3 isoform X1

    Conserved Domains (2) summary
    cd07156
    Location:21 → 92
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
    cl11397
    Location:116 → 318
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  2. XM_011238743.2 → XP_011237045.1  nuclear receptor subfamily 1 group I member 3 isoform X2

    Conserved Domains (2) summary
    cd07156
    Location:21 → 92
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
    cl11397
    Location:116 → 281
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RNA

  1. XR_373594.4 RNA Sequence

  2. XR_373595.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35627.2 GenPept UniProtKB/Swiss-Prot:O35627

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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