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Runx3 runt related transcription factor 3 [ Mus musculus (house mouse) ]

Gene ID: 12399, updated on 28-Oct-2024

Summary

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Official Symbol
Runx3provided by MGI
Official Full Name
runt related transcription factor 3provided by MGI
Primary source
MGI:MGI:102672
See related
Ensembl:ENSMUSG00000070691 AllianceGenome:MGI:102672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rx3; AML2; Cbfa3; Pebp2a3
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of epithelial cell proliferation; negative regulation of transcription by RNA polymerase II; and regulation of alpha-beta T cell differentiation. Acts upstream of or within several processes, including chondrocyte differentiation; hair follicle morphogenesis; and positive regulation of extrinsic apoptotic signaling pathway. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Used to study asthma; idiopathic scoliosis; and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); female reproductive organ cancer (multiple); lung non-small cell carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human RUNX3 (RUNX family transcription factor 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in spleen adult (RPKM 11.1), thymus adult (RPKM 6.0) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Runx3 in Genome Data Viewer
Location:
4 D3; 4 67.19 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134847956..134905301)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135120645..135177990)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene DRG (dorsal root ganglion) regulatory region upstream of Runx3 Neighboring gene predicted gene, 42327 Neighboring gene STARR-positive B cell enhancer ABC_E6232 Neighboring gene predicted gene 16225 Neighboring gene STARR-positive B cell enhancer ABC_E1659 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:134762237-134762420 Neighboring gene STARR-positive B cell enhancer mm9_chr4:134781869-134782170 Neighboring gene chloride intracellular channel 4 Neighboring gene STARR-positive B cell enhancer ABC_E3528 Neighboring gene STARR-positive B cell enhancer ABC_E7998 Neighboring gene VISTA enhancer mm1648 Neighboring gene STARR-positive B cell enhancer ABC_E524 Neighboring gene predicted gene, 30767

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Runx3 regulates folliculogenesis and steroidogenesis in granulosa cells of immature mice. Ojima F, et al. Cell Tissue Res, 2019 Mar. PMID 30377784
  2. Growth regulation of gastric epithelial cells by Runx3. Fukamachi H, et al. Oncogene, 2004 May 24. PMID 15156189
  3. Runx3-/- gastric epithelial cells differentiate into intestinal type cells. Fukamachi H, et al. Biochem Biophys Res Commun, 2004 Aug 13. PMID 15358215
  4. Abnormal liver differentiation and excessive angiogenesis in mice lacking Runx3. Lee JM, et al. Histochem Cell Biol, 2013 May. PMID 23370707
  5. Carcinogen-induced skin tumor development requires leukocytic expression of the transcription factor Runx3. Bauer O, et al. Cancer Prev Res (Phila), 2014 Sep. PMID 24961879

See all (276) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation.
    Title: USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation.
  2. Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma.
    Title: Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma.
  3. RUNX3 alleviates mitochondrial dysfunction and tubular damage by inhibiting TLR4/NF-kappaB signalling pathway in diabetic kidney disease.
    Title: RUNX3 alleviates mitochondrial dysfunction and tubular damage by inhibiting TLR4/NF-κB signalling pathway in diabetic kidney disease.
  4. Combination of androgen and estrogen improves asthma by mediating Runx3 expression.
    Title: Combination of androgen and estrogen improves asthma by mediating Runx3 expression.
  5. Runx3 Regulates CD8[+] T Cell Local Expansion and CD43 Glycosylation in Mice by H1N1 Influenza A Virus Infection.
    Title: Runx3 Regulates CD8(+) T Cell Local Expansion and CD43 Glycosylation in Mice by H1N1 Influenza A Virus Infection.
  6. Runx3 Restoration Regresses K-Ras-Activated Mouse Lung Cancers and Inhibits Recurrence.
    Title: Runx3 Restoration Regresses K-Ras-Activated Mouse Lung Cancers and Inhibits Recurrence.
  7. Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
    Title: Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
  8. Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesis.
    Title: Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesis.
  9. RUNX3 inactivates oncogenic MYC through disruption of MYC/MAX complex and subsequent recruitment of GSK3beta-FBXW7 cascade.
    Title: RUNX3 inactivates oncogenic MYC through disruption of MYC/MAX complex and subsequent recruitment of GSK3β-FBXW7 cascade.
  10. Enforced expression of Runx3 improved CAR-T cell potency in solid tumor via enhancing resistance to activation-induced cell death.
    Title: Enforced expression of Runx3 improved CAR-T cell potency in solid tumor via enhancing resistance to activation-induced cell death.
Submit: New GeneRIF Correction See all GeneRIFs (140)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell maturation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chondrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chondrocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hemopoiesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of CD4-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ossification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to transforming growth factor beta ISO
Inferred from Sequence Orthology
more info
  
involved_in response to transforming growth factor beta ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within type II interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of core-binding factor complex TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
runt-related transcription factor 3
Names
CBF-alpha-3
PEA2-alpha C
PEBP2-alpha C
SL3-3 enhancer factor 1 alpha C subunit
SL3/AKV core-binding factor alpha C subunit
acute myeloid leukemia 2 protein
core binding factor alpha 3
core-binding factor subunit alpha-3
oncogene AML-2
polyomavirus enhancer-binding protein 2 alpha C subunit
runt domain, alpha subunit 3
transcription factor AML2/CBFA3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369050.1 → NP_001355979.1  runt-related transcription factor 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL731718
    Consensus CDS
    CCDS89843.1
    UniProtKB/Swiss-Prot
    B2FDG4, Q64131, Q99P92, Q9R199
    Related
    ENSMUSP00000113159.2, ENSMUST00000119564.2
    Conserved Domains (2) summary
    pfam00853
    Location:63 → 184
    Runt; Runt domain
    pfam08504
    Location:314 → 409
    RunxI; Runx inhibition domain

  2. NM_019732.2 → NP_062706.2  runt-related transcription factor 3 isoform 1

    See identical proteins and their annotated locations for NP_062706.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK155436, AL731718
    Consensus CDS
    CCDS18782.1
    UniProtKB/TrEMBL
    Q3U1Q3
    Related
    ENSMUSP00000050353.8, ENSMUST00000056977.14
    Conserved Domains (2) summary
    pfam00853
    Location:77 → 198
    Runt; Runt domain
    pfam08504
    Location:328 → 423
    RunxI; Runx inhibition domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    134847956..134905301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538506.5 → XP_006538569.1  runt-related transcription factor 3 isoform X1

    See identical proteins and their annotated locations for XP_006538569.1

    Conserved Domains (2) summary
    pfam00853
    Location:1 → 74
    Runt; Runt domain
    pfam08504
    Location:204 → 299
    RunxI; Runx inhibition domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64131.3 GenPept UniProtKB/Swiss-Prot:Q64131

Gene LinkOut

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