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LOC124403920 Sharpr-MPRA regulatory region 7684 [ Homo sapiens (human) ]

Gene ID: 124403920, updated on 10-Oct-2023

Summary

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Gene symbol
LOC124403920
Gene description
Sharpr-MPRA regulatory region 7684
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional repressive element by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in HepG2 liver carcinoma cells (group: HepG2 Repressive non-DNase unmatched - State 15:Elon, transcription elongation, stronger H3K36me3, more exonic). [provided by RefSeq, Feb 2022]
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Genomic context

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See LOC124403920 in Genome Data Viewer
Location:
10p
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (21673680..21673974)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (21692786..21693080)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (21962609..21962903)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene MLLT10 histone lysine methyltransferase DOT1L cofactor Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:21952461-21953111 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:21954039-21954538 Neighboring gene RNA, U6 small nuclear 1141, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:21999974-22000474 Neighboring gene uncharacterized LOC107984214 Neighboring gene NANOG hESC enhancer GRCh37_chr10:22015451-22015952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:22036939-22037438 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:22039902-22041101 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:22041514-22042174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:22042835-22043494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:22043495-22044154 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:22045403-22046279 Neighboring gene DnaJ heat shock protein family (Hsp40) member C1 Neighboring gene RN7SK pseudogene 219

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_079000.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    21673680..21673974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    21692786..21693080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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