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LOC124489747 Sharpr-MPRA regulatory region 3465 [ Homo sapiens (human) ]

Gene ID: 124489747, updated on 10-Oct-2023

Summary

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Gene symbol
LOC124489747
Gene description
Sharpr-MPRA regulatory region 3465
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional repressive element by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Repressive non-DNase unmatched - State 12:CtcfO, distal CTCF/candidate insulator with open chromatin). [provided by RefSeq, Mar 2022]
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Genomic context

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Location:
11q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (61628157..61628451)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (61617026..61617320)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene synaptotagmin 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3396 Neighboring gene uncharacterized LOC105369331 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61354237-61354816 Neighboring gene uncharacterized LOC101927495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61355975-61356553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61366831-61367498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61368167-61368834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61393636-61394198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61394199-61394759 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61396115-61397096 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61406067-61406567 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:61406607-61407134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:61408188-61408713 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:61430561-61431253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61450060-61450734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61450735-61451408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61457781-61458312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61458313-61458844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61462776-61463302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61462250-61462775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61463303-61463829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61465411-61465936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61465937-61466463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61466990-61467516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61467517-61468042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61468570-61469095 Neighboring gene diacylglycerol lipase alpha Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61482486-61483272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61483273-61484058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61484845-61485630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61485631-61486417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61486418-61487203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61487991-61488775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61507907-61508480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61514637-61515498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61516359-61517220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3398 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:61523524-61524723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61524877-61525520 Neighboring gene MYRF antisense RNA 1 Neighboring gene myelin regulatory factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_079308.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    61628157..61628451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    61617026..61617320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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