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Cd48 CD48 antigen [ Mus musculus (house mouse) ]

Gene ID: 12506, updated on 2-Nov-2024

Summary

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Official Symbol
Cd48provided by MGI
Official Full Name
CD48 antigenprovided by MGI
Primary source
MGI:MGI:88339
See related
Ensembl:ENSMUSG00000015355 AllianceGenome:MGI:88339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BCM1; BLAST; Bcm-1; BLAST1; SLAMF2; Sgp-60; BLAST-1; MEM-102
Summary
Acts upstream of or within T cell activation and signal transduction. Located in external side of plasma membrane. Is expressed in several structures, including adipose tissue; bone; hemolymphoid system; liver; and lung. Orthologous to human CD48 (CD48 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 16.9), thymus adult (RPKM 12.5) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Cd48 in Genome Data Viewer
Location:
1 H3; 1 79.54 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171508989..171532825)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171681245..171705258)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 9 Neighboring gene STARR-positive B cell enhancer ABC_E5848 Neighboring gene SLAM family member 7 Neighboring gene STARR-positive B cell enhancer ABC_E5849 Neighboring gene STARR-positive B cell enhancer ABC_E800 Neighboring gene microRNA 7683 Neighboring gene STARR-positive B cell enhancer ABC_E11696 Neighboring gene STARR-positive B cell enhancer ABC_E2586 Neighboring gene translational machinery associated 7 homolog (S. cerevisiae), pseudogene Neighboring gene adaptor-related protein complex 3, sigma 1 subunit pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CD48-deficient mice have a pronounced defect in CD4(+) T cell activation. González-Cabrero J, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927686, Free PMC Article
  2. Identification, by protein sequencing and gene transfection, of sgp-60 as the murine homologue of CD48. Cabrero JG, et al. Proc Natl Acad Sci U S A, 1993 Apr 15. PMID 8475091, Free PMC Article
  3. The murine Cd48 gene: allelic polymorphism in the IgV-like region. Cabrero JG, et al. Eur J Immunogenet, 1998 Dec. PMID 9949948
  4. The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis. Koh AE, et al. J Autoimmun, 2011 Aug. PMID 21561736, Free PMC Article
  5. CD48 controls T-cell and antigen-presenting cell functions in experimental colitis. Abadía-Molina AC, et al. Gastroenterology, 2006 Feb. PMID 16472597

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48.
    Title: Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48.
  2. Boosting of tau protein aggregation by CD40 and CD48 gene expression in Alzheimer's disease.
    Title: Boosting of tau protein aggregation by CD40 and CD48 gene expression in Alzheimer's disease.
  3. Molecular dynamic simulation explains unbinding and unfolding of CD48-2B4 protein complexes.
    Title: Unbinding and unfolding of adhesion protein complexes through stretching: interplay between shear and tensile mechanical clamps.
  4. These data demonstrate the important role of CD48 in SA/exotoxins-eosinophil activating interactions that can take place during allergic responses and indicate CD48 as a novel therapeutic target for allergy and especially of AD.
    Title: The CD48 receptor mediates Staphylococcus aureus human and murine eosinophil activation.
  5. ORMDL3 promotes eosinophil trafficking and activation via regulation of CD18, CD49d, and CD48.
    Title: ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48.
  6. Ox-LDL significantly promoted the interaction of natural killer cells and dendritic cells via CD48-2B4 contact-dependent mechanisms.
    Title: Ox-LDL can enhance the interaction of mice natural killer cells and dendritic cells via the CD48-2B4 pathway.
  7. B6-specific background genes modulate the effect of CD48 on lupus nephritis in a recessive manner
    Title: The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis.
  8. CD48 plays a vital role as an environmental sensor for regulating hematopoietic stem cells and progenitor cell numbers and inhibiting tumor development
    Title: CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation.
  9. CD48 on surrounding NK or non-NK cells serves primarily as a ligand to stimulate 2B4 on the adjacent NK cells in mice
    Title: Unidirectional signaling triggered through 2B4 (CD244), not CD48, in murine NK cells.
  10. CD137 and CD28 can promote bcl-2 expression at both mRNA and protein level in T cells.
    Title: [Regulation of Bcl-2 expression in ageing T cells by CD137 and CD28].
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mast cell activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CD48 antigen
Names
BCM1 surface antigen
HM48-1
MRC OX-45 surface antigen
SLAM family member 2
signaling lymphocytic activation molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360767.1 → NP_001347696.1  CD48 antigen isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC091521
    Consensus CDS
    CCDS87923.1
    UniProtKB/TrEMBL
    F8WHM0, Q8C2T1
    Related
    ENSMUSP00000015499.8, ENSMUST00000015499.14
    Conserved Domains (1) summary
    cd05775
    Location:33 → 124
    Ig_CD2_like_N; N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2 and similar domains

  2. NM_007649.5 → NP_031675.1  CD48 antigen isoform 1 precursor

    See identical proteins and their annotated locations for NP_031675.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC091521, AK084984
    Consensus CDS
    CCDS15501.1
    UniProtKB/Swiss-Prot
    P18181, Q545K2
    UniProtKB/TrEMBL
    Q18PH8, Q6P905
    Related
    ENSMUSP00000064241.6, ENSMUST00000068584.7
    Conserved Domains (2) summary
    smart00410
    Location:29 → 110
    IG_like; Immunoglobulin like
    cl11960
    Location:36 → 124
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171508989..171532825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496637.4 → XP_006496700.1  CD48 antigen isoform X2

  2. XM_006496636.2 → XP_006496699.1  CD48 antigen isoform X1

    UniProtKB/TrEMBL
    Q18PH8, Q6P905
    Conserved Domains (1) summary
    cd05775
    Location:33 → 124
    Ig_CD2_like_N; N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2 and similar domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18181.1 GenPept UniProtKB/Swiss-Prot:P18181

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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