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LOC125177408 Sharpr-MPRA regulatory region 481 [ Homo sapiens (human) ]

Gene ID: 125177408, updated on 10-Oct-2023

Summary

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Gene symbol
LOC125177408
Gene description
Sharpr-MPRA regulatory region 481
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional repressive element by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Repressive non-DNase unmatched - State 16:ElonW, transcriptional elongation, weaker H3K36me3). [provided by RefSeq, Apr 2022]
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Genomic context

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See LOC125177408 in Genome Data Viewer
Location:
17p
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4859854..4860148)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4750048..4750341)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8045 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:4711183-4712382 Neighboring gene phospholipase D2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4735692-4736478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8047 Neighboring gene misshapen like kinase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4752245-4752960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4752961-4753674 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:4757141-4758092 Neighboring gene ATPase H+ transporting V0 subunit c pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11550 Neighboring gene RNA, 7SL, cytoplasmic 784, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11551 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4805105-4805746 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4805747-4806388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11552 Neighboring gene Sharpr-MPRA regulatory region 10924 Neighboring gene chromosome 17 open reading frame 107 Neighboring gene cholinergic receptor nicotinic epsilon subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_080465.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    4859854..4860148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    4750048..4750341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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