Mia MIA SH3 domain containing [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Miaprovided by MGI
Official Full Name: MIA SH3 domain containingprovided by MGI
Primary source: MGI:MGI:109615
See related: Ensembl:ENSMUSG00000089661 AllianceGenome:MGI:109615
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mia1; Cdrap; CD-RAP
Summary: Predicted to enable growth factor activity. Acts upstream of or within cell-matrix adhesion and extracellular matrix organization. Predicted to be located in extracellular region. Is expressed in several structures, including articular cartilage; autopod; respiratory system; sensory organ; and skeleton. Orthologous to human MIA (MIA SH3 domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in limb E14.5 (RPKM 50.9), genital fat pad adult (RPKM 27.5) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 15.84 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (26879166..26880574, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (27179741..27181149, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MIA/CD-RAP Regulates MMP13 and Is a Potential New Disease-Modifying Target for Osteoarthritis Therapy.
Title: MIA/CD-RAP Regulates MMP13 and Is a Potential New Disease-Modifying Target for Osteoarthritis Therapy.
MIA is a regulator of cellular senescence in human and murine melanocytes.
Title: Role of melanoma inhibitory activity in melanocyte senescence.
The effects of MIA/CD-RAP on transcriptional regulation in chondrocytes, through the regulation of p54(nrb) via YBX1 contributes to the understanding of chondrogenesis.
Title: YBX1 is a modulator of MIA/CD-RAP-dependent chondrogenesis.
Attenuated LM expressing MIA.
Title: Inhibitory effect of live-attenuated Listeria monocytogenes-based vaccines expressing MIA gene on malignant melanoma.
as observed in other knockout models of molecules important for cartilage development and differentiation, viability and functional integrity is reached by remarkable molecular redundancy in MIA/CD-RAP knockout mice.
Title: Redundancy in regulation of chondrogenesis in MIA/CD-RAP-deficient mice.
The cartilage protein melanoma inhibitory activity contributes to inflammatory arthritis.
Title: The cartilage protein melanoma inhibitory activity contributes to inflammatory arthritis.
Expression analysis of cartilage tissue derived from MIA-/- mice revealed strong downregulation of nuclear RNA-binding protein 54-kDa.
Title: Enhanced cartilage regeneration in MIA/CD-RAP deficient mice.
MIA/CD-RAP stabilizes cartilage differentiation and inhibits differentiation into bone potentially by regulating signaling processes during differentiation.
Title: Modulation of cartilage differentiation by melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP).
Microarray analysis showed significant reductions in the expression of several proteins in lung misexpressing MIA.
Title: Misexpression of MIA disrupts lung morphogenesis and causes neonatal death.
A potential tumor suppressor role of Mia/Cd-rap in pituitary cells.
Title: The Mia/Cd-rap gene expression is downregulated by the high-mobility group A proteins in mouse pituitary adenomas.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Markers

Mia1 (e-PCR), detects polymorphism
- UniSTS:516440

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: melanoma-derived growth regulatory protein

Names: cartilage-derived retinoic acid-sensitive protein; melanoma inhibitory activity 1; melanoma inhibitory activity protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.