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Cetn3 centrin 3 [ Mus musculus (house mouse) ]

Gene ID: 12626, updated on 2-Nov-2024

Summary

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Official Symbol
Cetn3provided by MGI
Official Full Name
centrin 3provided by MGI
Primary source
MGI:MGI:1097706
See related
Ensembl:ENSMUSG00000021537 AllianceGenome:MGI:1097706
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MmCEN3
Summary
Enables G-protein beta/gamma-subunit complex binding activity and microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization. Located in centriole; ciliary basal body; and photoreceptor connecting cilium. Is expressed in several structures, including foregut; musculoskeletal system; nervous system; sensory organ; and submandibular gland primordium. Orthologous to human CETN3 (centrin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 18.1), CNS E11.5 (RPKM 17.0) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Cetn3 in Genome Data Viewer
Location:
13 C3; 13 43.68 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (81928201..81945274)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (81780636..81797155)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35131 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide G Neighboring gene STARR-positive B cell enhancer ABC_E11550 Neighboring gene metallo-beta-lactamase domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_35132 Neighboring gene STARR-positive B cell enhancer ABC_E604 Neighboring gene STARR-positive B cell enhancer ABC_E3088 Neighboring gene STARR-positive B cell enhancer ABC_E7258 Neighboring gene STARR-seq mESC enhancer starr_35135 Neighboring gene STARR-seq mESC enhancer starr_35136 Neighboring gene predicted gene, 32836 Neighboring gene STARR-seq mESC enhancer starr_35138 Neighboring gene predicted gene, 41008

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of both centrin 2 (CETN2) and CETN3 destabilizes the distal connecting cilium of mouse photoreceptors. Ying G, et al. J Biol Chem, 2019 Mar 15. PMID 30647131, Free PMC Article
  2. Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene. Middendorp S, et al. Proc Natl Acad Sci U S A, 1997 Aug 19. PMID 9256449, Free PMC Article
  3. Centrin4p, a novel mammalian centrin specifically expressed in ciliated cells. Gavet O, et al. Mol Biol Cell, 2003 May. PMID 12802058, Free PMC Article
  4. PRCD is concentrated at the base of photoreceptor outer segments and is involved in outer segment disc formation. Allon G, et al. Hum Mol Genet, 2019 Dec 15. PMID 31628458
  5. Light-dependent CK2-mediated phosphorylation of centrins regulates complex formation with visual G-protein. Trojan P, et al. Biochim Biophys Acta, 2008 Jun. PMID 18269917

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein beta/gamma-subunit complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary transition zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore nuclear basket ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore nuclear basket ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor connecting cilium IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription export complex 2 ISO
Inferred from Sequence Orthology
more info
  
part_of transcription export complex 2 ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
centrin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007684.4 → NP_031710.1  centrin-3

    See identical proteins and their annotated locations for NP_031710.1

    Status: VALIDATED

    Source sequence(s)
    AI851499, AK006891, BY103593
    Consensus CDS
    CCDS26663.1
    UniProtKB/Swiss-Prot
    O35648
    UniProtKB/TrEMBL
    Q545L8, Q9CYN1, Q9D046
    Related
    ENSMUSP00000022009.9, ENSMUST00000022009.10
    Conserved Domains (1) summary
    PTZ00183
    Location:15 → 166
    PTZ00183; centrin; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    81928201..81945274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517074.5 → XP_006517137.1  centrin-3 isoform X1

    UniProtKB/TrEMBL
    Q9CYN1
    Conserved Domains (1) summary
    PTZ00183
    Location:15 → 157
    PTZ00183; centrin; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35648.1 GenPept UniProtKB/Swiss-Prot:O35648

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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