U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HSPB6 heat shock protein family B (small) member 6 [ Homo sapiens (human) ]

Gene ID: 126393, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
HSPB6provided by HGNC
Official Full Name
heat shock protein family B (small) member 6provided by HGNC
Primary source
HGNC:HGNC:26511
See related
Ensembl:ENSG00000004776 MIM:610695; AllianceGenome:HGNC:26511
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEL55; Hsp20; PPP1R91
Summary
This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012]
Expression
Biased expression in fat (RPKM 483.5), heart (RPKM 239.6) and 8 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See HSPB6 in Genome Data Viewer
Location:
19q13.12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35754566..35757029, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38299879..38302342, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36245467..36247930, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36238731-36239245 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36239246-36239760 Neighboring gene presenilin enhancer, gamma-secretase subunit Neighboring gene lin-37 DREAM MuvB core complex component Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36248182-36248753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14501 Neighboring gene proline and serine rich 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36257953-36258804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14502 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36268039-36268924 Neighboring gene Rho GTPase activating protein 33 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36268925-36269809 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36275082-36275900

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. HSP20 Exerts a Protective Effect on Preeclampsia by Regulating Function of Trophoblast Cells Via Akt Pathways. Li F, et al. Reprod Sci, 2019 Jul. PMID 30305007
  2. Expression of heat shock protein 20 inversely correlated with tumor progression in patients with ovarian cancer. Qiao N, et al. Eur J Gynaecol Oncol, 2014. PMID 25423708
  3. Decreased expression of heat shock protein 20 in colorectal cancer and its implication in tumorigenesis. Ju YT, et al. J Cell Biochem, 2015 Feb. PMID 25187324
  4. Phosphorylation and activation of a transducible recombinant form of human HSP20 in Escherichia coli. Flynn CR, et al. Protein Expr Purif, 2007 Mar. PMID 17084643, Free PMC Article
  5. Molecular structure and dynamics of the dimeric human small heat shock protein HSPB6. Weeks SD, et al. J Struct Biol, 2014 Mar. PMID 24382496

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A prospective diagnostic model for breast cancer utilizing machine learning to examine the molecular immune infiltrate in HSPB6.
    Title: A prospective diagnostic model for breast cancer utilizing machine learning to examine the molecular immune infiltrate in HSPB6.
  2. Inhibition of HSP20 Ameliorates Steatotic Liver Disease by Stimulating ERK2-Dependent Autophagy.
    Title: Inhibition of HSP20 Ameliorates Steatotic Liver Disease by Stimulating ERK2-Dependent Autophagy.
  3. HSPB6 Deficiency Promotes the Development of Aortic Dissection and Rupture.
    Title: HSPB6 Deficiency Promotes the Development of Aortic Dissection and Rupture.
  4. Overexpression of HSPB6 inhibits osteosarcoma progress through the ERK signaling pathway.
    Title: Overexpression of HSPB6 inhibits osteosarcoma progress through the ERK signaling pathway.
  5. Cellular functions of heat shock protein 20 (HSPB6) in cancer: A review.
    Title: Cellular functions of heat shock protein 20 (HSPB6) in cancer: A review.
  6. HSPB6 Is Depleted in Colon Cancer Patients and Its Expression Is Induced by 5-aza-2'-Deoxycytidine In Vitro.
    Title: HSPB6 Is Depleted in Colon Cancer Patients and Its Expression Is Induced by 5-aza-2'-Deoxycytidine In Vitro.
  7. Prevalence of HSPB6 gene variants in peripartum cardiomyopathy: Data from the German PPCM registry.
    Title: Prevalence of HSPB6 gene variants in peripartum cardiomyopathy: Data from the German PPCM registry.
  8. Physico-chemical properties of two point mutants of small heat shock protein HspB6 (Hsp20) with abrogated cardioprotection.
    Title: Physico-chemical properties of two point mutants of small heat shock protein HspB6 (Hsp20) with abrogated cardioprotection.
  9. Effect of Arginine on Chaperone-Like Activity of HspB6 and Monomeric 14-3-3zeta.
    Title: Effect of Arginine on Chaperone-Like Activity of HspB6 and Monomeric 14-3-3ζ.
  10. HSP20 affects the invasiveness of extravillous trophoblast cells via Akt signaling pathway, and the its dysregulation might contribute to the pathophysiology of pre-eclampsia.
    Title: HSP20 Exerts a Protective Effect on Preeclampsia by Regulating Function of Trophoblast Cells Via Akt Pathways.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ32389

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of eye lens IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to heat IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
heat shock protein beta-6
Names
epididymis luminal protein 55
epididymis secretory sperm binding protein
heat shock 20 kDa-like protein p20
heat shock protein family B (small) member B6
heat shock protein family B member 6
heat shock protein, alpha-crystallin-related, B6
protein phosphatase 1, regulatory subunit 91

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031983.2 RefSeqGene

    Range
    5001..7464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_144617.3 → NP_653218.1  heat shock protein beta-6

    See identical proteins and their annotated locations for NP_653218.1

    Status: REVIEWED

    Source sequence(s)
    AK026458, AK056951, BC068046
    Consensus CDS
    CCDS12475.1
    UniProtKB/Swiss-Prot
    O14551, O14558, Q6NVI3, Q96MG9
    UniProtKB/TrEMBL
    A0A384MEB1, V9HWB6
    Related
    ENSP00000004982.3, ENST00000004982.6
    Conserved Domains (2) summary
    cd06478
    Location:66 → 144
    ACD_HspB4-5-6; Alpha-crystallin domain found in alphaA-crystallin (HspB4), alphaB-crystallin (HspB5), and the small heat shock protein (sHsp) HspB6, also known as Hsp20. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, ...
    pfam00525
    Location:3 → 58
    Crystallin; Alpha crystallin A chain, N terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35754566..35757029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    38299879..38302342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14558.2 GenPept UniProtKB/Swiss-Prot:O14558

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools