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CYP4F22 cytochrome P450 family 4 subfamily F member 22 [ Homo sapiens (human) ]

Gene ID: 126410, updated on 10-Dec-2024

Summary

Official Symbol
CYP4F22provided by HGNC
Official Full Name
cytochrome P450 family 4 subfamily F member 22provided by HGNC
Primary source
HGNC:HGNC:26820
See related
Ensembl:ENSG00000171954 MIM:611495; AllianceGenome:HGNC:26820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LI3; ARCI5; INLNE
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 11.5), esophagus (RPKM 6.1) and 3 other tissues See more
Orthologs
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Genomic context

See CYP4F22 in Genome Data Viewer
Location:
19p13.12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (15508525..15552317)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (15633518..15677350)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15619336..15663128)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14188 Neighboring gene RAS protein activator like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14190 Neighboring gene peptidoglycan recognition protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15618980-15619480 Neighboring gene staufen double-stranded RNA binding protein 1 pseudogene Neighboring gene MPRA-validated peak3387 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14191 Neighboring gene cytochrome P450 family 4 subfamily F member 23, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10285 Neighboring gene uncharacterized LOC124904644

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ39501

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monooxygenase activity TAS
Traceable Author Statement
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ceramide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in icosanoid metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ultra-long-chain fatty acid omega-hydroxylase
Names
cytochrome P450 4F22
cytochrome P450, family 2, subfamily E, polypeptide 2 homolog
cytochrome P450, family 4, subfamily F, polypeptide 22
NP_775754.2
XP_011525994.1
XP_011525995.1
XP_054175788.1
XP_054175789.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007987.1 RefSeqGene

    Range
    5001..48793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173483.4NP_775754.2  ultra-long-chain fatty acid omega-hydroxylase

    See identical proteins and their annotated locations for NP_775754.2

    Status: REVIEWED

    Source sequence(s)
    AC011492, AI341068, BC069351, DA874258
    Consensus CDS
    CCDS12331.1
    UniProtKB/Swiss-Prot
    Q6NT55, Q8N8H4
    UniProtKB/TrEMBL
    A0A1B1SMS2
    Related
    ENSP00000269703.1, ENST00000269703.8
    Conserved Domains (1) summary
    pfam00067
    Location:60524
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    15508525..15552317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527692.3XP_011525994.1  ultra-long-chain fatty acid omega-hydroxylase isoform X1

    See identical proteins and their annotated locations for XP_011525994.1

    UniProtKB/Swiss-Prot
    Q6NT55, Q8N8H4
    UniProtKB/TrEMBL
    A0A1B1SMS2
    Conserved Domains (1) summary
    pfam00067
    Location:60524
    p450; Cytochrome P450
  2. XM_011527693.3XP_011525995.1  ultra-long-chain fatty acid omega-hydroxylase isoform X1

    See identical proteins and their annotated locations for XP_011525995.1

    UniProtKB/Swiss-Prot
    Q6NT55, Q8N8H4
    UniProtKB/TrEMBL
    A0A1B1SMS2
    Conserved Domains (1) summary
    pfam00067
    Location:60524
    p450; Cytochrome P450

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    15633518..15677350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319813.1XP_054175788.1  ultra-long-chain fatty acid omega-hydroxylase isoform X1

    UniProtKB/Swiss-Prot
    Q6NT55, Q8N8H4
    UniProtKB/TrEMBL
    A0A1B1SMS2
  2. XM_054319814.1XP_054175789.1  ultra-long-chain fatty acid omega-hydroxylase isoform X1

    UniProtKB/Swiss-Prot
    Q6NT55, Q8N8H4
    UniProtKB/TrEMBL
    A0A1B1SMS2