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LOC126653331 BRD4-independent group 4 enhancer GRCh37_chr21:27511930-27513129 [ Homo sapiens (human) ]

Gene ID: 126653331, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126653331
Gene description
BRD4-independent group 4 enhancer GRCh37_chr21:27511930-27513129
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Aug 2022]
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Genomic context

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See LOC126653331 in Genome Data Viewer
Location:
chromosome: 21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (26139612..26140811)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (24497751..24498950)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372756 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27290380-27290953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27290954-27291526 Neighboring gene amyloid beta precursor protein Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:27326978-27328177 Neighboring gene RNA, U6 small nuclear 123, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:27333032-27333727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18320 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:27360167-27360668 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:27369694-27370507 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27370508-27371320 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:27395669-27396168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27451148-27451673 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr21:27452711-27453576 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:27453577-27454444 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:27454445-27455310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27456082-27456619 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr21:27479739-27480384 Neighboring gene uncharacterized LOC124900466 Neighboring gene NANOG hESC enhancer GRCh37_chr21:27521254-27521823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13235 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:27542299-27542823 Neighboring gene APP divergent transcript Neighboring gene RNA, U6 small nuclear 926, pseudogene Neighboring gene myristoylated alanine rich protein kinase C substrate pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_081824.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    26139612..26140811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    24497751..24498950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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