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LOC126653361 CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:37780832-37782031 [ Homo sapiens (human) ]

Gene ID: 126653361, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126653361
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:37780832-37782031
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Aug 2022]
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Genomic context

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See LOC126653361 in Genome Data Viewer
Location:
chromosome: 21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (36408534..36409733)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (34791113..34792312)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13284 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:37708895-37710094 Neighboring gene MORC family CW-type zinc finger 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:37737075-37737251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:37758141-37758642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:37758643-37759142 Neighboring gene ATP synthase membrane subunit f pseudogene 1 Neighboring gene chromatin assembly factor 1 subunit B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37802462-37803337 Neighboring gene CLDN14 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37836794-37837391 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:37842779-37843278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18436 Neighboring gene claudin 14 Neighboring gene proteasome 26S subunit, non-ATPase 4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18437 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13288 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:37973046-37973546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:37973547-37974047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:37978989-37979489 Neighboring gene uncharacterized LOC105369308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:38031419-38031920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:38031921-38032420 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr21:38067894-38068806

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_081854.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    36408534..36409733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    34791113..34792312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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