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LOC126653392 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:44144061-44145260 [ Homo sapiens (human) ]

Gene ID: 126653392, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126653392
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:44144061-44145260
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Aug 2022]
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Genomic context

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See LOC126653392 in Genome Data Viewer
Location:
chromosome: 21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (42723951..42725150)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (41112320..41113519)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1671 Neighboring gene MPRA-validated peak4415 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44037913-44038824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44057507-44058403 Neighboring gene uncharacterized LOC101928255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44072695-44073416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44081521-44082390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44086147-44086653 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44088149-44089095 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44089096-44090041 Neighboring gene phosphodiesterase 9A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44122945-44123824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44126986-44127486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44158941-44159941 Neighboring gene PDE9A antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44176879-44177378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44181049-44181582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44181583-44182114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44187499-44187998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44191023-44191524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44195549-44196050 Neighboring gene uncharacterized LOC107985504

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_081885.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    42723951..42725150
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    41112320..41113519
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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