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LOC126805603 CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7798026-7799225 [ Homo sapiens (human) ]

Gene ID: 126805603, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126805603
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7798026-7799225
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126805603 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (7737966..7739165)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (7269012..7270211)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (7798026..7799225)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene calmodulin binding transcription activator 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7563077-7563934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7563935-7564790 Neighboring gene uncharacterized LOC105376691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7565577-7566214 Neighboring gene MPRA-validated peak35 silencer Neighboring gene MPRA-validated peak36 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7594027-7595006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7598278-7598983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7643497-7643996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7646449-7647169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7655704-7656204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7668502-7669038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7670114-7670651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7669577-7670113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7669039-7669576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7672975-7673506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7673507-7674037 Neighboring gene MPRA-validated peak37 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7685250-7685750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7695174-7696155 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7700515-7701015 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7702117-7703085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7703871-7704371 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7710763-7711264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7711265-7711764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7717029-7717568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7723269-7723770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 90 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7729239-7730085 Neighboring gene translation initiation factor IF-2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 185 Neighboring gene MPRA-validated peak40 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:7830560-7831256 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:7831283-7831525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 187 Neighboring gene uncharacterized LOC124903833 Neighboring gene MPRA-validated peak42 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7886590-7887789 Neighboring gene vesicle associated membrane protein 3 Neighboring gene period circadian regulator 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_081927.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    7737966..7739165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    7269012..7270211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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