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LOC126805862 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:151964375-151965574 [ Homo sapiens (human) ]

Gene ID: 126805862, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126805862
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:151964375-151965574
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126805862 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151991899..151993098)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (151115419..151116619)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151964375..151965574)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene thioesterase superfamily member 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:151870195-151871394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151878733-151879272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1727 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:151882372-151882959 Neighboring gene Sharpr-MPRA regulatory region 4547 Neighboring gene uncharacterized LOC124904421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1331 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:151909054-151909699 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:151918150-151918685 Neighboring gene keratin 8 pseudogene 28 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151941289-151941789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1332 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1334 Neighboring gene S100 calcium binding protein A10 Neighboring gene Sharpr-MPRA regulatory region 9275 Neighboring gene uncharacterized LOC105371442 Neighboring gene NBPF member 18, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10037 Neighboring gene Sharpr-MPRA regulatory region 201 Neighboring gene S100 calcium binding protein A11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082186.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    151991899..151993098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    151115419..151116619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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