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LOC126806351 MED14-independent group 3 enhancer GRCh37_chr2:134742538-134743737 [ Homo sapiens (human) ]

Gene ID: 126806351, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126806351
Gene description
MED14-independent group 3 enhancer GRCh37_chr2:134742538-134743737
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126806351 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (133984967..133986166)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (134424476..134425675)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (134742538..134743737)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NCK associated protein 5 Neighboring gene NCKAP5 intron CAGE-defined mid-level expression enhancer Neighboring gene RN7SK pseudogene 154 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:134227836-134228352 Neighboring gene NANOG hESC enhancer GRCh37_chr2:134401501-134402008 Neighboring gene RN7SK pseudogene 93 Neighboring gene Sharpr-MPRA regulatory region 15675 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:134575595-134576794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16541 Neighboring gene uncharacterized LOC105373627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16542 Neighboring gene uncharacterized LOC105373628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16543 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:134821977-134822608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16544 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:134864951-134865484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:134866541-134867202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:134867203-134867862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11972 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11974 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11975 Neighboring gene microRNA 3679 Neighboring gene alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082671.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    133984967..133986166
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    134424476..134425675
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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