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LOC126806627 CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:23390324-23391523 [ Homo sapiens (human) ]

Gene ID: 126806627, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806627
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:23390324-23391523
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (23348833..23350032)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (23353875..23355074)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19590 Neighboring gene RPL24 pseudogene 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:23243491-23244466 Neighboring gene UBE2E2 divergent transcript Neighboring gene ubiquitin conjugating enzyme E2 E2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19592 Neighboring gene MPRA-validated peak4575 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19595 Neighboring gene C11orf98 pseudogene 3 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68697 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68737 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:23547704-23548204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:23548205-23548705 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68793 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:23631277-23631776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19597 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:23650116-23650712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:23650713-23651308 Neighboring gene RNA, U6 small nuclear 922, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_082947.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    23348833..23350032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    23353875..23355074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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