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LOC126859589 BRD4-independent group 4 enhancer GRCh37_chr6:11722447-11723646 [ Homo sapiens (human) ]

Gene ID: 126859589, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859589
Gene description
BRD4-independent group 4 enhancer GRCh37_chr6:11722447-11723646
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126859589 in Genome Data Viewer
Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (11722214..11723413)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (11590451..11591650)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:11538275-11538776 Neighboring gene transmembrane protein 170B Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:11609547-11610088 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:11650363-11650968 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:11650969-11651574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16917 Neighboring gene uncharacterized LOC340184 Neighboring gene small nucleolar RNA SNORA67 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23991 Neighboring gene uncharacterized LOC124901258 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_88259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23993 Neighboring gene androgen dependent TFPI regulating protein Neighboring gene ReSE screen-validated silencer GRCh37_chr6:11763549-11763791 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:11770197-11770720 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr6:11770721-11771242 and GRCh37_chr6:11771243-11771766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:11794232-11794800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:11794801-11795369 Neighboring gene uncharacterized LOC107986567 Neighboring gene uncharacterized LOC124901257

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084090.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    11722214..11723413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    11590451..11591650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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