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LOC126859680 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:44610400-44611599 [ Homo sapiens (human) ]

Gene ID: 126859680, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859680
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:44610400-44611599
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (44642663..44643862)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (44477331..44478530)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375074 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44510389-44511019 Neighboring gene uncharacterized LOC105375075 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:44588544-44589128 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44592119-44592626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44592627-44593135 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44594661-44595168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44595169-44595676 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44597530-44598150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44598773-44599392 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:44619143-44619644 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:44619645-44620144 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44634844-44635352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44636371-44636878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24641 Neighboring gene uncharacterized LOC124901325 Neighboring gene uncharacterized LOC101929770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24643 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44727363-44727954 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:44739389-44740008 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44838634-44839257 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44846566-44847066 Neighboring gene SPT3 homolog, SAGA and STAGA complex component Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91988 Neighboring gene NUDT19 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084181.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    44642663..44643862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    44477331..44478530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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