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LOC126859744 MED14-independent group 3 enhancer GRCh37_chr6:91617235-91618434 [ Homo sapiens (human) ]

Gene ID: 126859744, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859744
Gene description
MED14-independent group 3 enhancer GRCh37_chr6:91617235-91618434
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (90907517..90908716)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (92118802..92120002)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901363 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17400 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:91296727-91296923 Neighboring gene NANOG hESC enhancer GRCh37_chr6:91307010-91307575 Neighboring gene mitogen-activated protein kinase kinase kinase 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:91319600-91320100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:91320101-91320601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17401 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:91321559-91322507 Neighboring gene uncharacterized LOC107986623 Neighboring gene uncharacterized LOC105377893 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:91379294-91380249 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:91380250-91381204 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:91383116-91384071 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:91384072-91385026 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:91385983-91386936 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:91388246-91389050 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:91489789-91490333 Neighboring gene NANOG hESC enhancer GRCh37_chr6:91624822-91625331 Neighboring gene NANOG hESC enhancer GRCh37_chr6:91867325-91867853 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:92007857-92008449 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:92008450-92009041 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:92009042-92009634 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:92009635-92010225 Neighboring gene uncharacterized LOC107986624 Neighboring gene Sharpr-MPRA regulatory region 15648 Neighboring gene MPRA-validated peak5963 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24837 Neighboring gene microRNA 4643

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084245.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    90907517..90908716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    92118802..92120002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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