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LOC126859778 CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:125849225-125850424 [ Homo sapiens (human) ]

Gene ID: 126859778, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859778
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:125849225-125850424
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (125528079..125529278)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (126716572..126717771)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986640 Neighboring gene uncharacterized LOC102723341 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:125711176-125711724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:125765831-125766344 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:125766345-125766856 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:125854657-125855265 Neighboring gene NANOG hESC enhancer GRCh37_chr6:125870255-125870862 Neighboring gene HEY2 antisense RNA 1 Neighboring gene MPRA-validated peak6111 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:125991600-125992310 Neighboring gene long intergenic non-protein coding RNA 2523 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:126023017-126023671 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:126028243-126028789 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:126028790-126029335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25029 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:126066495-126067162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17518 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17519 Neighboring gene hes related family bHLH transcription factor with YRPW motif 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084279.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    125528079..125529278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    126716572..126717771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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