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LOC126859788 MED14-independent group 3 enhancer GRCh37_chr6:131677980-131679179 [ Homo sapiens (human) ]

Gene ID: 126859788, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859788
Gene description
MED14-independent group 3 enhancer GRCh37_chr6:131677980-131679179
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126859788 in Genome Data Viewer
Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (131356840..131358039)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (132551292..132552491)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723445 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_89797 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:131456238-131456738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25063 Neighboring gene NANOG hESC enhancer GRCh37_chr6:131460844-131461345 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:131463068-131463791 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:131464515-131465238 Neighboring gene MPRA-validated peak6126 silencer Neighboring gene A-kinase anchoring protein 7 Neighboring gene double PHD fingers 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25065 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:131547081-131547840 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_89836 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:131602472-131602980 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:131602981-131603489 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:131613147-131613647 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:131616173-131616853 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:131621535-131622042 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:131622043-131622551 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:131644204-131644992 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:131649720-131650506 Neighboring gene NANOG hESC enhancer GRCh37_chr6:131657722-131658239 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:131659077-131660032 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:131660033-131660988 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:131661945-131662898 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:131665584-131666271 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:131664895-131665583 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:131664207-131664894 Neighboring gene uncharacterized LOC105378005 Neighboring gene ribosomal protein L21 pseudogene 67 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:131825416-131826081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:131852503-131853004 Neighboring gene NANOG hESC enhancer GRCh37_chr6:131893832-131894333 Neighboring gene mediator complex subunit 23 Neighboring gene arginase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084289.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    131356840..131358039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    132551292..132552491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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