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LOC126859919 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:807142-808341 [ Homo sapiens (human) ]

Gene ID: 126859919, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859919
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:807142-808341
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. A subregion was also validated as an enhancer by ChIP-STARR-seq in naive human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Dec 2022]
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Genomic context

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Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (767505..768704)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (870600..871799)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:643285-643970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25473 Neighboring gene PRKAR1B antisense RNA 1 Neighboring gene uncharacterized LOC105375119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:653082-653582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:653583-654083 Neighboring gene MPRA-validated peak6334 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:690976-692175 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:715563-715737 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:736050-736550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:736551-737051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17818 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:770503-771002 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:791462-792661 Neighboring gene dynein axonemal assembly factor 5 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:821444-822643 Neighboring gene uncharacterized LOC124901567 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:837226-837726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:849762-850262 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:850239-850399 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:853271-853834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:852706-853270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:855273-856014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17821 Neighboring gene Sharpr-MPRA regulatory region 7003 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:869831-870726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25474 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:871666-872865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25475 Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene uncharacterized LOC124901568

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:807791-808318

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084420.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    767505..768704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    870600..871799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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