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LOC126859933 CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:4303312-4304511 [ Homo sapiens (human) ]

Gene ID: 126859933, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859933
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:4303312-4304511
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126859933 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (4263680..4264879)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (4380471..4381643)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene sidekick cell adhesion molecule 1 Neighboring gene uncharacterized LOC124901576 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:4007911-4009110 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:4079787-4080423 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:4080424-4081059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4082400-4082925 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:4118749-4118965 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4128978-4129522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4142403-4142903 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4147017-4147598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4145852-4146434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4148767-4149268 Neighboring gene uncharacterized LOC105375131 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4175261-4176143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4176144-4177025 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4186737-4187351 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4208580-4209080 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:4214126-4214549 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4221387-4221887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4220886-4221386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4226243-4226988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4229670-4230550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4234799-4235418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4237901-4238400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4242006-4242522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4242523-4243039 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4245119-4245620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4245621-4246120 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4256703-4257426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4265444-4265945 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4265946-4266446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4276819-4277320 Neighboring gene NANOG hESC enhancer GRCh37_chr7:4279685-4280186 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:4299431-4300630 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:4347010-4347752 Neighboring gene uncharacterized LOC124901578 Neighboring gene uncharacterized LOC124901579

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084434.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    4263680..4264879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    4380471..4381643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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