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LOC126859934 MED14-independent group 3 enhancer GRCh37_chr7:4777977-4779176 [ Homo sapiens (human) ]

Gene ID: 126859934, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859934
Gene description
MED14-independent group 3 enhancer GRCh37_chr7:4777977-4779176
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126859934 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (4738346..4739545)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (4855552..4856751)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 13 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4739232-4739732 Neighboring gene forkhead box K1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4742083-4742842 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4744443-4745084 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4745727-4746368 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4746369-4747010 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4747011-4747652 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4747653-4748294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4748937-4749577 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4750899-4751431 Neighboring gene uncharacterized LOC124901581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4763724-4764310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4776642-4777196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4779416-4779969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4779970-4780524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17900 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4789475-4789974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4793383-4793937 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:4800052-4801251 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4813996-4814672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4814673-4815349 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25566 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4832559-4833233 Neighboring gene adaptor related protein complex 5 subunit zeta 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17904 Neighboring gene microRNA 4656 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4847903-4848404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4848405-4848904 Neighboring gene Rap associating with DIL domain Neighboring gene small nucleolar RNA, C/D box 165

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084435.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    4738346..4739545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    4855552..4856751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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