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LOC126859982 BRD4-independent group 4 enhancer GRCh37_chr7:31032726-31033925 [ Homo sapiens (human) ]

Gene ID: 126859982, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859982
Gene description
BRD4-independent group 4 enhancer GRCh37_chr7:31032726-31033925
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126859982 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (30993111..30994310)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (31130755..31131954)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr7:30961348-30961528 Neighboring gene aquaporin 1 (Colton blood group) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25820 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:31014486-31014664 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18074 Neighboring gene uncharacterized LOC105375222 Neighboring gene growth hormone releasing hormone receptor Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:31024083-31024608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:31029507-31030287 Neighboring gene uncharacterized LOC105375221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:31066433-31067036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:31067037-31067640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:31082296-31082796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:31082797-31083297 Neighboring gene ADCYAP receptor type I Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:31109473-31109974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:31117973-31118706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:31141510-31142010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:31145675-31146470 Neighboring gene small integral membrane protein 14-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084483.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    30993111..30994310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    31130755..31131954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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