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LOC126859997 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:37071299-37072498 [ Homo sapiens (human) ]

Gene ID: 126859997, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859997
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:37071299-37072498
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. A subregion was also validated as an enhancer by ChIP-STARR-seq in primed human embryonic stem cells, where it associates with the NANOG transcription factor and is marked by the H3K27ac histone modification. [provided by RefSeq, Dec 2022]
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Genomic context

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Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (37031694..37032893)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (37172034..37173233)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene engulfment and cell motility 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25847 Neighboring gene microRNA 1200 Neighboring gene MPRA-validated peak6484 silencer Neighboring gene Sharpr-MPRA regulatory region 8653 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:37052330-37053529 Neighboring gene ELMO1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25851 Neighboring gene NANOG hESC enhancer GRCh37_chr7:37156919-37157420 Neighboring gene origin-enriched sequence 8 Neighboring gene ribosomal protein S17 pseudogene 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:37193283-37193902 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • NANOG-H3K27ac hESC enhancer GRCh37_chr7:37071333-37072002

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084498.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    37031694..37032893
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    37172034..37173233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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