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LOC126860039 BRD4-independent group 4 enhancer GRCh37_chr7:51293750-51294949 [ Homo sapiens (human) ]

Gene ID: 126860039, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860039
Gene description
BRD4-independent group 4 enhancer GRCh37_chr7:51293750-51294949
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860039 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (51226053..51227252)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (51387279..51388490)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50920730-50921230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50921231-50921731 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50935547-50936047 Neighboring gene ribosomal protein L39 pseudogene 23 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:50954893-50955392 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:50966118-50966911 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:50966912-50967704 Neighboring gene MPRA-validated peak6518 silencer Neighboring gene small nucleolar RNA SNORA4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:51030815-51031330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:51077377-51077878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:51080078-51080578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:51080579-51081079 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:51130441-51130946 Neighboring gene cordon-bleu WH2 repeat protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:51178901-51179402 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:51198256-51198477 Neighboring gene Sharpr-MPRA regulatory region 13396 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:51235321-51236520 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:51242789-51243404 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:51243405-51244020 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:51244021-51244636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:51255465-51256071 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:51256072-51256677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:51281381-51281880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:51292168-51292876 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:51292877-51293585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:51296486-51297359 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:51297491-51297624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:51301551-51302070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:51305304-51305844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:51311515-51312015 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:51330459-51331274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:51341365-51341866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:51341867-51342366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:51342802-51343798 Neighboring gene RPL7L1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:51371041-51371540 Neighboring gene uncharacterized LOC124901633 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:51384764-51385357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:51385358-51385950

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084540.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    51226053..51227252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    51387279..51388490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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