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LOC126860047 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:55200333-55201532 [ Homo sapiens (human) ]

Gene ID: 126860047, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860047
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:55200333-55201532
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. A subregion was also validated as an enhancer by ChIP-STARR-seq in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Dec 2022]
Annotation information
Note: This locus has been reviewed for its involvement in coronavirus biology, and is regulatory element in the vicinity of coronavirus related gene(s).
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Genomic context

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Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (55132640..55133839)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (55292533..55293732)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 5 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55049579-55050078 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:55052801-55054000 Neighboring gene uncharacterized LOC105375284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55087710-55088384 Neighboring gene epidermal growth factor receptor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:55134605-55135181 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:55141370-55142569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26010 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:55198912-55199819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26011 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:55214270-55214808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55219798-55220606 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:55223847-55225046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55248893-55249512 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:55249513-55250132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:55253294-55254067 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:55259777-55260662 Neighboring gene EGFR antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55281927-55282427 Neighboring gene OCT4 hESC enhancer GRCh37_chr7:55304767-55305286 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:55307850-55309049 Neighboring gene solute carrier family 19 member 3 pseudogene Neighboring gene EGFR long non-coding downstream RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:55200473-55201472

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084548.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    55132640..55133839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    55292533..55293732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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