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LOC126860090 BRD4-independent group 4 enhancer GRCh37_chr7:83337804-83339003 [ Homo sapiens (human) ]

Gene ID: 126860090, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860090
Gene description
BRD4-independent group 4 enhancer GRCh37_chr7:83337804-83339003
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860090 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (83708488..83709687)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (84958967..84960166)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene semaphorin 3E Neighboring gene uncharacterized LOC105375378 Neighboring gene NANOG hESC enhancer GRCh37_chr7:83126208-83126709 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:83314287-83314786 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:83315470-83315977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:83320326-83320837 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:83322516-83323158 Neighboring gene RAD23B pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26217 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:83463173-83463673 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18337 Neighboring gene uncharacterized LOC107986745 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:83623841-83624402 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:83624403-83624963 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:83631626-83632189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26218 Neighboring gene semaphorin 3A Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:83684131-83684722 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:83684723-83685314 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:83720483-83720983 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:83779267-83779791 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:83779792-83780315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:83795422-83795922 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:83824219-83825026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:83835322-83836064 Neighboring gene OCT4-NANOG hESC enhancers GRCh37_chr7:83857426-83857944 and GRCh37_chr7:83857945-83858461 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:83880131-83881330 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:83906806-83907406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26219 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:84001008-84002207 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_100327 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_100336 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_100364

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084591.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    83708488..83709687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    84958967..84960166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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