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LOC126860120 BRD4-independent group 4 enhancer GRCh37_chr7:98445139-98446338 [ Homo sapiens (human) ]

Gene ID: 126860120, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860120
Gene description
BRD4-independent group 4 enhancer GRCh37_chr7:98445139-98446338
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (98847516..98848715)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (100080827..100082026)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375418 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:98359523-98360022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:98383282-98383812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:98383813-98384343 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26309 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18397 Neighboring gene RNA, U6 small nuclear 393, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:98423765-98424340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:98448603-98449104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:98450701-98451422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:98466535-98467121 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:98467122-98467707 Neighboring gene transmembrane protein 130 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18399 Neighboring gene small nucleolar RNA U13 Neighboring gene small Cajal body-specific RNA 28 Neighboring gene microRNA 3609 Neighboring gene transformation/transcription domain associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084621.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    98847516..98848715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    100080827..100082026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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