U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126860175 MED14-independent group 3 enhancer GRCh37_chr7:129649077-129650276 [ Homo sapiens (human) ]

Gene ID: 126860175, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126860175
Gene description
MED14-independent group 3 enhancer GRCh37_chr7:129649077-129650276
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. In HCT116 colorectal carcinoma cells, a subregion was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. Another subregion was also validated as an enhancer by ChIP-STARR-seq in naive human embryonic stem cells, where it is marked by the H3K4me1 histone modification. [provided by RefSeq, Jan 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (130008941..130010436)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (131322291..131323784)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129416778-129417624 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18634 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129420163-129421008 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129421855-129422700 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129422701-129423545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129424259-129424770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129424771-129425281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26634 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:129426816-129427326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129427327-129427837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129427838-129428347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129432262-129432762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129439452-129440063 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129442015-129442516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129442517-129443016 Neighboring gene microRNA 183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18637 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26635 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129474501-129475160 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:129475895-129476430 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:129478138-129479337 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129482500-129483326 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129483327-129484153 Neighboring gene ubiquitin conjugating enzyme E2 H Neighboring gene NANOG hESC enhancer GRCh37_chr7:129519616-129520117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26636 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:129585761-129586260 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:129588587-129589160 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129589161-129589732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26637 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18639 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18640 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:129606459-129606647 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129608210-129608852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129608853-129609494 Neighboring gene UBE2H divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129630785-129631284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129646338-129646838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129646839-129647339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26640 Neighboring gene RNA, 5S ribosomal pseudogene 245 Neighboring gene zinc finger C3HC-type containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129690548-129691340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26644 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26645 Neighboring gene kelch domain containing 10

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

General gene information

Go to the top of the page Help

Other Names

  • H3K4me1 hESC enhancer GRCh37_chr7:129648781-129649280

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084676.2 

    Range
    101..1596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    130008941..130010436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    131322291..131323784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases