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LOC126860190 CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:134877948-134879147 [ Homo sapiens (human) ]

Gene ID: 126860190, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860190
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:134877948-134879147
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (135193196..135194395)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (136501056..136502255)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene AGBL carboxypeptidase 3 Neighboring gene cell cycle regulator of NHEJ Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26702 Neighboring gene RNF14 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18676 Neighboring gene transmembrane protein 140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26712 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134888580-134888794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18677 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:134893611-134894810 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18678 Neighboring gene WD repeat domain 91 Neighboring gene microRNA 6509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26713 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134935285-134935435 Neighboring gene uncharacterized LOC107984123 Neighboring gene stimulated by retinoic acid 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084691.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    135193196..135194395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    136501056..136502255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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