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LOC126860215 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:145750296-145751495 [ Homo sapiens (human) ]

Gene ID: 126860215, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860215
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:145750296-145751495
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860215 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (146053203..146054402)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (147233271..147234471)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375553 Neighboring gene MPRA-validated peak6819 silencer Neighboring gene MPRA-validated peak6820 silencer Neighboring gene uncharacterized LOC124901765 Neighboring gene MPRA-validated peak6822 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr7:145629475-145629976 Neighboring gene NANOG hESC enhancer GRCh37_chr7:145694161-145694662 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:145715805-145716394 Neighboring gene MPRA-validated peak6823 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:145858210-145858754 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:145945721-145946492 Neighboring gene contactin associated protein 2 Neighboring gene transmembrane protein 183A pseudogene Neighboring gene MPRA-validated peak6825 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:146485317-146485842 Neighboring gene Sharpr-MPRA regulatory region 553 Neighboring gene NANOG hESC enhancer GRCh37_chr7:146572321-146572837 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:146602536-146603152 Neighboring gene CNTNAP2 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084716.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    146053203..146054402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    147233271..147234471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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