U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126860216 BRD4-independent group 4 enhancer GRCh37_chr7:147868766-147869965 [ Homo sapiens (human) ]

Gene ID: 126860216, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126860216
Gene description
BRD4-independent group 4 enhancer GRCh37_chr7:147868766-147869965
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (148171674..148172873)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (149351663..149352862)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene contactin associated protein 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_97821 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:147605052-147605552 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:147605553-147606053 Neighboring gene RNA, 5S ribosomal pseudogene 249 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:147696507-147697163 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:147697164-147697819 Neighboring gene NANOG hESC enhancer GRCh37_chr7:147708749-147709250 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:147717495-147718281 Neighboring gene RNA, 7SL, cytoplasmic 456, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26798 Neighboring gene Sharpr-MPRA regulatory region 9018 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:147977203-147977403 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:147987619-147988173 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:148012335-148012894 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148024709-148025285 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148032138-148033043 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148036315-148036845 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:148037465-148038070 Neighboring gene uncharacterized LOC105375554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:148080395-148080896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:148080897-148081398 Neighboring gene small nucleolar RNA U3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148092562-148093198 Neighboring gene RNA, 7SL, cytoplasmic 72, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084717.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    148171674..148172873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    149351663..149352862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases