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LOC126860854 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:7403871-7405070 [ Homo sapiens (human) ]

Gene ID: 126860854, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860854
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:7403871-7405070
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (7361909..7363108)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (7361627..7362826)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Scm like with four mbt domains 2 Neighboring gene small nucleolar RNA, C/D box 129 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:7298769-7299968 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:7371119-7371620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2974 Neighboring gene uncharacterized LOC124902372 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:7407161-7407660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:7449871-7450766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:7453245-7454165 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:7454166-7455085 Neighboring gene uncharacterized LOC124902373 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:7487564-7487770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:7488827-7489326 Neighboring gene long intergenic non-protein coding RNA 2642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2977 Neighboring gene NANOG hESC enhancer GRCh37_chr10:7500249-7500813 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2979

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085353.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    7361909..7363108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    7361627..7362826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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