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LOC126860863 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:12490405-12491604 [ Homo sapiens (human) ]

Gene ID: 126860863, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860863
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:12490405-12491604
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860863 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (12448406..12449605)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (12460717..12461920)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3037 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:12267705-12268640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:12268641-12269574 Neighboring gene FOXA motif-containing MPRA enhancer 241 Neighboring gene cell division cycle 123 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2139 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:12306176-12306714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12365022-12365522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12365523-12366023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2143 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:12391861-12392360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3040 Neighboring gene RNA, 7SL, cytoplasmic 198, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12430241-12430740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12430790-12431290 Neighboring gene calcium/calmodulin dependent protein kinase ID Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3042 Neighboring gene RNA, U6atac small nuclear 39, pseudogene Neighboring gene uncharacterized LOC107984209

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085362.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    12448406..12449605
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    12460717..12461920
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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