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LOC126860905 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:31531588-31532787 [ Homo sapiens (human) ]

Gene ID: 126860905, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860905
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:31531588-31532787
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (31242659..31243858)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (31272401..31273588)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 438 Neighboring gene MPRA-validated peak916 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3231 Neighboring gene DEAD-box helicase 10 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2271 Neighboring gene uncharacterized LOC105376481 Neighboring gene MPRA-validated peak918 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3233 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3234 Neighboring gene uncharacterized LOC105376482 Neighboring gene uncharacterized LOC105376483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2273 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31435102-31435653 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31435654-31436204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31498085-31498585 Neighboring gene long intergenic non-protein coding RNA 2664 Neighboring gene RNA, 5S ribosomal pseudogene 309 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2276 Neighboring gene ZEB1 antisense RNA 1 Neighboring gene zinc finger E-box binding homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085404.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    31242659..31243858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    31272401..31273588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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