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LOC126860952 CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:73006150-73007349 [ Homo sapiens (human) ]

Gene ID: 126860952, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860952
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:73006150-73007349
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. In HCT116 colorectal carcinoma cells, a subregion was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. Another subregion was also validated as an enhancer by ChIP-STARR-seq in naive human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Jan 2023]
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Genomic context

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Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (71246168..71247592)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (72115792..72117216)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378351 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72765166-72765964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72800281-72800928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72821681-72822446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72837401-72838351 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72892357-72892910 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2459 Neighboring gene Sharpr-MPRA regulatory region 4082 Neighboring gene NANOG hESC enhancer GRCh37_chr10:72975354-72975973 Neighboring gene uncharacterized LOC112268061 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72980575-72981076 Neighboring gene UNC5B antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72992253-72992763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72992809-72993562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72995071-72995822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72995831-72996578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72996579-72997325 Neighboring gene unc-5 netrin receptor B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73019454-73020306 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73025690-73026683 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:73026875-73027596 Neighboring gene Sharpr-MPRA regulatory region 4598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73030481-73031200 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73039115-73039640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73038590-73039114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73044725-73045226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73045227-73045726 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:73055217-73056024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:73063697-73064197 Neighboring gene uncharacterized LOC124902445 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2461 Neighboring gene small nucleolar RNA U13 Neighboring gene solute carrier family 29 member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73005925-73006844

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085451.2 

    Range
    101..1525
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    71246168..71247592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    72115792..72117216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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