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LOC126860969 CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:79627013-79628212 [ Homo sapiens (human) ]

Gene ID: 126860969, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860969
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:79627013-79628212
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860969 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (77867255..77868454)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (78736318..78737517)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1266, pseudogene Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 5 Neighboring gene discs large MAGUK scaffold protein 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:79568517-79569016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:79591709-79592210 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:79592211-79592710 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:79596052-79596324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79596746-79597366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79601269-79601770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79613571-79614072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79614073-79614572 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79616089-79616612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79616613-79617136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79623439-79624198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79625716-79626473 Neighboring gene Sharpr-MPRA regulatory region 8551 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79637563-79638502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79649557-79650232 Neighboring gene uncharacterized LOC101929347 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79651583-79652256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79660915-79661442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79661443-79661970 Neighboring gene Sharpr-MPRA regulatory region 4447 Neighboring gene NFE2L2 motif-containing MPRA enhancers 69 and 123 Neighboring gene RNA, 7SL, cytoplasmic 284, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085468.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    77867255..77868454
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    78736318..78737517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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